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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Corona protein impacts on alternating current biosusceptometry signal and circulation times of differently coated MnFe2O4 nanoparticles

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Author(s):
Prospero, Andre Goncalves [1] ; Buranello, Lais Pereira [1] ; Fernandes, Carlos A. H. [1, 2] ; dos Santos, Lucilene Delazari [3, 4] ; Soares, Guilherme [1] ; Rossini, Bruno C. [3] ; Zufelato, Nicholas [5, 6] ; Bakuzis, Andris Figueiroa [5, 6] ; de Mattos Fontes, Marcos R. [1] ; de Arruda Miranda, Jose R. [1]
Total Authors: 10
Affiliation:
[1] Sao Paulo State Univ, Dept Biophys & Pharmacol, BR-18618689 Botucatu, SP - Brazil
[2] Sorbonne Univ, Inst Mineral Phys Mat & Cosmochim, CNRS, IMPMC, UMR 7590, Museum Natl Hist Nat, F-7590 Paris - France
[3] Sao Paulo State Univ, Biotechnol Inst, BR-18607440 Botucatu, SP - Brazil
[4] Sao Paulo State Univ, Botucatu Med Sch FMB, Grad Program Trop Dis, UNESP, BR-18618687 Botucatu, SP - Brazil
[5] Univ Fed Goias, Inst Phys, BR-74690900 Goiania, Go - Brazil
[6] Univ Fed Goias, CNanoMed, BR-74690900 Goiania, Go - Brazil
Total Affiliations: 6
Document type: Journal article
Source: Nanomedicine; v. 16, n. 24 SEP 2021.
Web of Science Citations: 0
Abstract

Background: We evaluated the impacts of corona protein (CP) formation on the alternating current biosusceptometry (ACB) signal intensity and in vivo circulation times of three differently coated magnetic nanoparticles (MNP): bare, citrate-coated and bovine serum albumin-coated MNPs. Methods: We employed the ACB system, gel electrophoresis and mass spectrometry analysis. Results: Higher CP formation led to a greater reduction in the in vitro ACB signal intensity and circulation time. We found fewer proteins forming the CP for the bovine serum albumin-coated MNPs, which presented the highest circulation time in vivo among the MNPs studied. Conclusion: These data showed better biocompatibility, stability and magnetic signal uniformity in biological media for bovine serum albumin-coated MNPs than for citrate-coated MNPs and bare MNPs. (AU)

FAPESP's process: 15/14923-9 - Instrumentation and applications by biosusceptometry alternating current: nanoparticles distribution studies, motility and quality control of solid dosage forms
Grantee:José Ricardo de Arruda Miranda
Support Opportunities: Regular Research Grants