| Full text | |
| Author(s): |
Brognara, Fernanda
[1]
;
Castania, Jaci Airton
[1]
;
Ribeiro, Aline Barbosa
[1]
;
Santos-Junior, Nilton Nascimento
[2]
;
Salgado, Helio Cesar
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Physiol, Ribeirao Preto - Brazil
[2] Minas Gerais State Univ, Passos - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | FRONTIERS IN PHYSIOLOGY; v. 12, SEP 20 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Evidence indicates that the activation of the parasympathetic branch of the autonomic nervous system may be effective in treating inflammatory diseases. Previously, we have described that baroreflex activation displays anti-inflammatory properties. Analogous to the baroreflex, the Bezold-Jarisch reflex also promotes parasympathetic activation with simultaneous inhibition of the sympathetic system. Thus, the present study aimed to evaluate whether the activation of the Bezold-Jarisch reflex would also have the ability to reduce inflammation in unanesthetized rats. We used lipopolysaccharide (LPS) injection (5mg/kg, i.p.) to induce systemic inflammation in male Wistar Hannover rats and phenylbiguanide (PBG) administration (5 mu g/kg, i.v.) to activate the Bezold-Jarisch reflex. Spleen, heart, hypothalamus, and blood samples were collected to determine the levels of cytokines. Compared to baseline, PBG reduced the arterial pressure (115 +/- 2 vs. 88 +/- 5mmHg) and heart rate (380 +/- 7 vs. 114 +/- 26bpm), immediately after its administration, confirming the activation of the parasympathetic system and inhibition of the sympathetic system. From the immunological point of view, the activation of the Bezold-Jarisch reflex decreased the plasma levels of TNF (LPS: 775 +/- 209 vs. PBG + LPS: 248 +/- 30pg/ml) and IL-6 levels in the spleen (LPS: 39 +/- 6 vs. PBG + LPS: 24 +/- 4pg/mg of tissue). However, it did not change the other cytokines in the plasma or the other tissues evaluated. These findings confirm that the activation of the Bezold-Jarisch reflex can modulate inflammation and support the understanding that the cardiovascular reflexes regulate the immune system.</p> (AU) | |
| FAPESP's process: | 13/20549-7 - NEW INSIGHTS IN CARDIOVASCULAR REGULATION UNDER PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL CONDITION |
| Grantee: | Helio Cesar Salgado |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 20/06043-7 - Autonomic (Sympathetic and Parasympathetic) Modulation of Cardiovascular and Inflammatory Responses under Physiopathological Clinical and Experimental Conditions. |
| Grantee: | Helio Cesar Salgado |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/10455-9 - Role of electrical activaton of the carotid sinus nerve, in conscious rats, in the attenuation of local and systemic inflammatory response elicited by periodontitis. |
| Grantee: | Aline Barbosa Ribeiro |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 18/20939-3 - New insights in Cardiovascular Regulation under Physiological and Pathophysiological Condition. |
| Grantee: | Nilton Nascimento dos Santos Júnior |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 17/05163-6 - ROLE OF THE PARASYMPATHETIC AND SYMPATHETIC AUTONOMIC NERVOUS SYSTEM IN THE MODULATION OF SEPSIS IN UNANESTHETIZED RATS |
| Grantee: | Fernanda Brognara Penteado Dias |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |