Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Bezold-Jarisch Reflex and The Inflammatory Response Modulation in Unanesthetized Endotoxemic Rats

Full text
Author(s):
Brognara, Fernanda [1] ; Castania, Jaci Airton [1] ; Ribeiro, Aline Barbosa [1] ; Santos-Junior, Nilton Nascimento [2] ; Salgado, Helio Cesar [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Physiol, Ribeirao Preto - Brazil
[2] Minas Gerais State Univ, Passos - Brazil
Total Affiliations: 2
Document type: Journal article
Source: FRONTIERS IN PHYSIOLOGY; v. 12, SEP 20 2021.
Web of Science Citations: 0
Abstract

Evidence indicates that the activation of the parasympathetic branch of the autonomic nervous system may be effective in treating inflammatory diseases. Previously, we have described that baroreflex activation displays anti-inflammatory properties. Analogous to the baroreflex, the Bezold-Jarisch reflex also promotes parasympathetic activation with simultaneous inhibition of the sympathetic system. Thus, the present study aimed to evaluate whether the activation of the Bezold-Jarisch reflex would also have the ability to reduce inflammation in unanesthetized rats. We used lipopolysaccharide (LPS) injection (5mg/kg, i.p.) to induce systemic inflammation in male Wistar Hannover rats and phenylbiguanide (PBG) administration (5 mu g/kg, i.v.) to activate the Bezold-Jarisch reflex. Spleen, heart, hypothalamus, and blood samples were collected to determine the levels of cytokines. Compared to baseline, PBG reduced the arterial pressure (115 +/- 2 vs. 88 +/- 5mmHg) and heart rate (380 +/- 7 vs. 114 +/- 26bpm), immediately after its administration, confirming the activation of the parasympathetic system and inhibition of the sympathetic system. From the immunological point of view, the activation of the Bezold-Jarisch reflex decreased the plasma levels of TNF (LPS: 775 +/- 209 vs. PBG + LPS: 248 +/- 30pg/ml) and IL-6 levels in the spleen (LPS: 39 +/- 6 vs. PBG + LPS: 24 +/- 4pg/mg of tissue). However, it did not change the other cytokines in the plasma or the other tissues evaluated. These findings confirm that the activation of the Bezold-Jarisch reflex can modulate inflammation and support the understanding that the cardiovascular reflexes regulate the immune system.</p> (AU)

FAPESP's process: 13/20549-7 - New insights in cardiovascular regulation under physiological and pathophysiological condition
Grantee:Helio Cesar Salgado
Support type: Research Projects - Thematic Grants
FAPESP's process: 20/06043-7 - Autonomic (sympathetic and parasympathetic) modulation of cardiovascular and inflammatory responses under physiopathological clinical and experimental conditions
Grantee:Helio Cesar Salgado
Support type: Research Projects - Thematic Grants
FAPESP's process: 18/10455-9 - Role of electrical activaton of the carotid sinus nerve, in conscious rats, in the attenuation of local and systemic inflammatory response elicited by periodontitis.
Grantee:Aline Barbosa Ribeiro
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 18/20939-3 - New insights in Cardiovascular Regulation under Physiological and Pathophysiological Condition.
Grantee:Nilton Nascimento dos Santos Júnior
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/05163-6 - Role of the parasympathetic and sympathetic autonomic nervous system in the modulation of sepsis in unanesthetized rats
Grantee:Fernanda Brognara Penteado Dias
Support type: Scholarships in Brazil - Doctorate (Direct)