Maxillary dentigerous cyst showing squamous odontogenic tumor-like proliferation: surgical approach and literature review

Author(s)

Camila de Oliveira Barbeiro ^[1] ; Roberto Henrique Barbeiro ^[2] ; Heitor Albergoni da Silveira ^[3] ; Luciana Yamamoto de Almeida ^[4] ; Jorge Esquiche León ^[5] ; Andreia Bufalino ^[6]

Affiliation

^[1] Universidade Estadual Paulista. Faculdade de Odontologia. Medicina Oral - Brasil

^[2] Universidade Estadual Paulista. Faculdade de Odontologia. Medicina Oral - Brasil

^[3] Universidade Estadual Paulista. Faculdade de Odontologia. Medicina Oral - Brasil

^[4] Universidade Estadual Paulista. Faculdade de Odontologia. Medicina Oral - Brasil

^[5] Universidade de São Paulo. Faculdade de Odontologia de Ribeirão Preto. Patologia Oral - Brasil

^[6] Universidade Estadual Paulista. Faculdade de Odontologia. Medicina Oral - Brasil

• Document type: Journal article
• Source: Autopsy and Case Reports; v. 11, 2021-07-02.

Abstract

ABSTRACT Squamous odontogenic tumor (SOT) is a rare benign neoplasm of the jaw that likely arises from remnants of the dental lamina. It is a slow-growing lesion, with a radiolucent appearance in the central variant. Microscopically, SOT shows islands of squamous epithelium supported by fibrous stroma. In rare cases, squamous odontogenic tumor-like proliferation (SOT-LP) can be observed arising from odontogenic cysts (SOT-LPOC). Herein, we describe the case of a 42-year-old man who presented with discreet bleeding in the maxillary gingiva. Imaging revealed a well-defined, ovoid-shaped lesion with sclerotic margins involving tooth #18 in the intraosseous location. Fine needle aspiration supported the cystic nature of the lesion. After surgery, microscopy revealed a dentigerous cyst showing SOT-LP features. There was no recurrence after a 3-year follow-up. To the best of our knowledge, this is the first report of a dentigerous cyst showing SOT-LP features in the maxilla. Such cysts should be identified to avoid misdiagnosis, with the finding having therapeutic and prognostic implications. (AU)

• FAPESP's process: 16/11419-0 - Clinicopathological correlation of the degree of differentiation, tetraspanin expression, viral agents and cell proliferation in a large sample of squamous cell carcinoma of the head and neck region.
• Grantee: Jorge Esquiche León
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/12734-2 - Comparative immunohistochemical characterization of dendritic cell subgroups and viral oncogenesis in oral and oropharyngeal squamous cell carcinoma
• Grantee: Heitor Albergoni da Silveira
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 17/01438-0 - The role of the innate and adaptive immune responses in oral leukoplakia and oral proliferative verrucous leukoplakia
• Grantee: Andreia Bufalino
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/04954-2 - Evaluation of the acetylation status of H3 histone and its contribution to genomic instability in oral leukoplakia and Proliferative Verrucous Leukoplakia
• Grantee: Camila de Oliveira Barbeiro
• Support Opportunities: Scholarships in Brazil - Master