| Full text | |
| Author(s): |
Pieretti, Joana C.
[1]
;
Beurton, Jordan
[2]
;
Munevar, Julian
[1]
;
Nagamine, Luiz C. C. M.
[3]
;
Le Faou, Alain
[2]
;
Seabra, Amedea B.
[1]
;
Clarot, Igor
[2]
;
Boudier, Ariane
[2]
Total Authors: 8
|
| Affiliation: | [1] Fed Univ ABC UFABC, Ctr Nat & Human Sci CCNH, BR-09210580 Santo Andre, SP - Brazil
[2] Univ Lorraine, CITHEFOR, F-54000 Nancy - France
[3] Univ Sao Paulo, Inst Fis, BR-05508090 Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 22, n. 19 OCT 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
In nanomedicine, hybrid nanomaterials stand out for providing new insights in both the diagnosis and treatment of several diseases. Once administered, engineered nanoparticles (NPs) interact with biological molecules, and the nature of this interaction might directly interfere with the biological fate and action of the NPs. In this work, we synthesized a hybrid magnetic nanostructure, with antibacterial and antitumoral potential applications, composed of a magnetite core covered by silver NPs, and coated with a modified chitosan polymer. As magnetite NPs readily oxidize to maghemite, we investigated the structural properties of the NPs after addition of the two successive layers using Mossbauer spectroscopy. Then, the structural characteristics of the NPs were correlated to their interaction with albumin, the major blood protein, to evidence the consequences of its binding on NP properties and protein retention. Thermodynamic parameters of the NPs-albumin interaction were determined. We observed that the more stable NPs (coated with modified chitosan) present a lower affinity for albumin in comparison to pure magnetite and magnetite/silver hybrid NPs. Surface properties were key players at the NP-biological interface. To the best of our knowledge, this is the first study that demonstrates a correlation between the structural properties of complex hybrid NPs and their interaction with albumin.</p> (AU) | |
| FAPESP's process: | 18/02832-7 - Hybrid magnetic and antibacterial nanoparticles: synthesis, characterization and applications |
| Grantee: | Joana Claudio Pieretti |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 19/07766-5 - Blood compatibility of hybrid magnetic/silver nanoparticles coated with nitric oxide donor |
| Grantee: | Joana Claudio Pieretti |
| Support Opportunities: | Scholarships abroad - Research Internship - Master's degree |