| Full text | |
| Author(s): |
Fraga, Layanne Nascimento
;
Coutinho, Camille Perella
;
Rozenbaum, Adriana Campos
;
Tobaruela, Eric de Castro
;
Lajolo, Franco Maria
;
Hassimotto, Neuza Mariko Aymoto
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Food Res Ctr FoRC, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | FOOD & FUNCTION; v. 12, n. 22 OCT 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Hesperidin and narirutin are the major flavanones present in orange juice, and they are associated with a reduction in risk of cardiometabolic disease. However, there is heterogeneity in their biological responses, which is partly due to the large interindividual variation in these flavonoids' bioavailability. We investigated the relation between interindividual variability in the excretion of phase II conjugates and gut-derived phenolic acids, and cardiometabolic biomarkers response. Seventy-four subjects, both men and women, were included in a single-arm study. Over the 60 days, volunteers consumed 500 mL of orange juice daily. All measurements and blood collections were performed before and after the intervention period. Moreover, 24 h urine collection was performed after first consumption. Individuals were stratified according to the excretion of phase II conjugates and, for the first time, according to phenolic acids in high, medium, and low excretors. Furthermore, for the first time, the ratio between phenolic acids and flavanones-phase II conjugates has shown groups with different metabolization patterns. Groups with a low or intermediate ratio, corresponding to a higher amount of phase II conjugates excreted, showed a significant reduction in body fat % and blood pressure. This finding suggests that these improvements could be associated in a major way to flavanones-phase II conjugates, as well as to phenolic acids and stratification of volunteers according to metabolite excretions could be a good strategy to better understand the effects of orange juice on metabolism and health. (AU) | |
| FAPESP's process: | 13/07914-8 - FoRC - Food Research Center |
| Grantee: | Bernadette Dora Gombossy de Melo Franco |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 20/06467-1 - Metabolomic and proteomic approaches to investigate the potental biological effects of fruits polyphenols |
| Grantee: | Eric de Castro Tobaruela |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |