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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Searching for bioactive compounds from Solanaceae: lethal and sublethal toxicity to Spodoptera frugiperda and untargeted metabolomics approaches

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Author(s):
Lima, Andreisa Fabri [1, 2] ; Ribeiro, Leandro do Prado [3] ; Padoan Goncalves, Gabriel Luiz [4] ; Maimone, Naydja Moralles [4] ; Gissi, Danilo Soares [5] ; de Lira, Simone Possedente [4] ; Vendramim, Jose Djair [2]
Total Authors: 7
Affiliation:
[1] Lavras Fed Univ UFLA, Dept Entomol, Lavras, MG - Brazil
[2] Univ Sao Paulo, Luiz de Queiroz Coll Agr, Dept Entomol & Acarol, USP, ESALQ, Piracicaba, SP - Brazil
[3] Agr Res & Rural Extens Co Santa Catarina EPAGRI C, Res Ctr Family Agr, Rua Ferdinando Ricieri Tusset S-N, BR-89801970 Chapeco, SC - Brazil
[4] Univ Sao Paulo, Luiz de Queiroz Coll Agr, Dept Exact Sci, USP, ESALQ, Piracicaba, SP - Brazil
[5] Sao Paulo State Univ, Dept Bot, UNESP, Botucatu, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: JOURNAL OF PEST SCIENCE; NOV 2021.
Web of Science Citations: 0
Abstract

The fall armyworm, Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae), is a major pest of maize crops and others row crops on the American continent, and this pest has spread to Africa and Asia. Such lepidopteran pest presents resistant populations to synthetic insecticides and to Bacillus thuringiensis (Bt) toxins and, consequently, new (bio) insecticides with distinct modes of action are required. In order to search for derivatives from Solanaceae as a potential source of bioactive compounds, a screening of 38 ethanolic extracts were prepared from 25 Solanaceae species. Using dietary exposure assessment, the ethanolic extracts from leaves of Acnistus arborescens (L.) Schltdl. and Datura stramonium L. were the most promising derivatives. A bioguided fractionation was performed with both plant species. The A. arborescens dichloromethane fraction was the most active, causing sublethal (growth inhibition) and lethal toxicity. Thus, this fraction was submitted to another fractionation procedure resulting in three subfractions (dichloromethane, ethyl acetate and methanol) that were tested against S. frugiperda caterpillars. All subfractions lead to significant sublethal effects, however, without significant mortality. The chemical diversity in the subfractions of A. arborescens was assessed through untargeted approaches, such as molecular networking and the in silico annotation tool NAP, by which two withanolides glycosides were annotated: (22R)-1-Oxo-3beta-(beta-D-glucopyranosyloxy)-14,20,22,27-tetrahydroxyerg osta-5,24-diene-26-oic acid delta-lactone and withanoside XI. Therefore, derivatives of Solanaceae present promising compounds that may be useful in the framework of S. frugiperda integrated pest management. In addition, metabolomics is an innovative alternative and powerful approach to facilitate the putative identification of compounds in studies of natural products. (AU)

FAPESP's process: 13/50228-8 - Biodiversity components, and their metabolic characters, of Brazilian Islands: an integrated approach
Grantee:Roberto Gomes de Souza Berlinck
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 09/54094-0 - Acquisition of a multi-stage mass spectrometer for a Laboratory / Facility in the Chemistry Department of the University of São Paulo Ribeirão Preto School of Philosophy, Science and Literature
Grantee:Luiz Alberto Beraldo de Moraes
Support Opportunities: Multi-user Equipment Program