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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Efficacy of a calcium-phosphate/fluoride varnish and ionomeric sealant on cervical dentin hypersensitivity: A randomized, double-blind, placebo-controlled clinical study

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Author(s):
Machado, Alana Cristina [1] ; Maximiano, Vinicius [1] ; Yoshida, Mirian Lumi [1] ; Freitas, Julia Gomes [2] ; Mendes, Fausto Medeiros [2] ; Aranha, Ana Cecilia Correa [3] ; Scaramucci, Tais [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Sch Dent, Dept Restorat Dent, Ave Prof Lineu Prestes 2227, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Sch Dent, Dept Pediat Dent, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Dent, Dept Restorat Dent, Special Lab Lasers LELO, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Oral Rehabilitation; v. 49, n. 1 NOV 2021.
Web of Science Citations: 0
Abstract

Background Dentin hypersensitivity (DH) is a common problem in the population that can have a significant impact on the quality of life of those who suffer from the condition. Objectives Compare the efficacy of two treatments for DH: Ca/PO4-/F- varnish (Clinpro White Varnish) and ionomeric sealant (IS) (Clinpro XT Varnish) with a placebo. Methods Participants (121) with at least one tooth with visual analogue scale (VAS) score of 4 and above were randomly and blindly allocated to the groups. Treatments were performed by a trained researcher. DH was evaluated by another blind researcher after the treatment and after 1 week, 4 weeks, 3 months and 6 months. After 4 weeks, placebo received the DH treatment with IS; thus, the participants were not assessed after 3 and 6 months. Primary outcome was DH reduction after 4 weeks. Differences in VAS scores in the other time intervals and entire values of VAS were considered secondary outcomes. Comparisons were made among the groups (alpha = 0.05). Results IS showed the highest VAS value difference between baseline and 4 weeks (mean +/- SD: 3.7 +/- 2.2), differing significantly from placebo (2.3 +/- 1.7) and Ca/PO4/F- varnish (2.6 +/- 2.0). Ca/PO4(-)/F- varnish did not differ from placebo. In all time intervals, VAS values of all groups were significantly lower than the baseline value, without differences among groups. For the long-term differences in VAS values (3 and 6 months), the IS exhibited significantly higher values than Ca/PO4(-)/F- varnish. Conclusions The IS was the most efficacious product for reducing DH, whereas Ca/PO4(-)/F- varnish did not differ from placebo. Registered in ClinicalTrials.gov (NCT04591444). (AU)

FAPESP's process: 17/24714-3 - Effect of the order of application of dentifrices and solutions containing fluorides and tin in the progression of erosive wear on enamel and bovine dentin - in situ study
Grantee:Alana Cristina Machado
Support Opportunities: Scholarships in Brazil - Doctorate