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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Marine alkaloids as bioactive agents against protozoal neglected tropical diseases and malaria

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Author(s):
Tempone, Andre G. [1] ; Pieper, Pauline [2] ; Borborema, Samanta E. T. [1] ; Thevenard, Fernanda [3] ; Lago, Joao Henrique G. [3] ; Croft, Simon L. [4] ; Anderson, Edward A. [2]
Total Authors: 7
Affiliation:
[1] Adolfo Lutz Inst, Ctr Parasitol & Mycol, BR-01246000 Sao Paulo - Brazil
[2] Univ Oxford, Chem Res Lab, 12 Mansfield Rd, Oxford OX1 3TA - England
[3] Fed Univ ABC, Ctr Nat Sci & Humanities, BR-09210580 Sao Paulo - Brazil
[4] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, London WC1E 7HT - England
Total Affiliations: 4
Document type: Review article
Source: NATURAL PRODUCT REPORTS; v. 38, n. 12, p. 2214-2235, DEC 15 2021.
Web of Science Citations: 3
Abstract

Covering: 2000 up to 2021 Natural products are an important resource in drug discovery, directly or indirectly delivering numerous small molecules for potential development as human medicines. Among the many classes of natural products, alkaloids have a rich history of therapeutic applications. The extensive chemodiversity of alkaloids found in the marine environment has attracted considerable attention for such uses, while the scarcity of these natural materials has stimulated efforts towards their total synthesis. This review focuses on the biological activity of marine alkaloids (covering 2000 to up to 2021) towards Neglected Tropical Diseases (NTDs) caused by protozoan parasites, and malaria. Chemotherapy represents the only form of treatment for Chagas disease, human African trypanosomiasis, leishmaniasis and malaria, but there is currently a restricted arsenal of drugs, which often elicit severe adverse effects, show variable efficacy or resistance, or are costly. Natural product scaffolds have re-emerged as a focus of academic drug discovery programmes, offering a different resource to discover new chemical entities with new modes of action. In this review, the potential of a range of marine alkaloids is analyzed, accompanied by coverage of synthetic efforts that enable further studies of key antiprotozoal natural product scaffolds. (AU)

FAPESP's process: 18/10279-6 - Selection and Optimization of New Drug Candidates for Leishmaniasis and Chagas Disease
Grantee:André Gustavo Tempone Cardoso
Support Opportunities: Regular Research Grants
FAPESP's process: 19/10434-4 - Cellular and molecular markers of therapeutic response of antihistamic drugs for the treatment of Visceral leishmaniasis
Grantee:Samanta Etel Treiger Borborema de Carvalho
Support Opportunities: Regular Research Grants
FAPESP's process: 18/07885-1 - Biomolecules from plant species of remnant areas of the Atlantic Forest and Cerrado to treat neglected tropical diseases - chemical and pharmacological aspects
Grantee:João Henrique Ghilardi Lago
Support Opportunities: BIOTA-FAPESP Program - Regular Research Grants