Norovirus strains in patients with acute gastroenteritis in rural and low-income urban areas in northern Brazil

Author(s):Show less -

Tinker, Rory J. ^{[1, 2]} ; da Costa, Antonio Charlys ^[1] ; Tahmasebi, Roozbeh ^[1] ; Milagres, Flavio Augusto de Padua ^{[3, 4]} ; dos Santos Morais, Vanessa ^[1] ; Pandey, Ramendra Pati ^[5] ; Jose-Abrego, Alexis ^[6] ; Brustulin, Rafael ^{[3, 4]} ; Rodrigues Teles, Maria da Aparecida ^[4] ; Cunha, Mariana Sequetin ^[7] ; Araujo, Emerson Luiz Lima ^[8] ; Gomez, Mariela Martinez ^[9] ; Deng, Xutao ^{[10, 11]} ; Delwart, Eric ^{[10, 11]} ; Sabino, Ester Cerdeira ^[1] ; Leal, Elcio ^[12] ; Luchs, Adriana ^[13]

Affiliation:Show less -

^[1] Univ Sao Paulo, Inst Med Trop, Sao Paulo - Brazil

^[2] Univ Manchester, Fac Biol Med & Hlth, Manchester, Lancs - England

^[3] Fed Univ Tocantins, Tocantins - Brazil

^[4] Publ Hlth Lab Tocantins State LACEN TO, Tocantins - Brazil

^[5] SRM Univ Delhi NCR, Ctr Drug Design Discovery & Dev, Sonepat - India

^[6] Civil Hosp Guadalajara Fray Antonio Alcalde, Dept Mol Biol Med, Guadalajara - Mexico

^[7] Adolfo Lutz Inst, Virol Ctr, Vectorborne Dis Lab, Sao Paulo - Brazil

^[8] Minist Hlth CGLAB DAEVS SVS MS, Gen Coordinat Publ Hlth Labs, Strateg Articulat Dept, Hlth Surveillance Secretariat, Brasilia, DF - Brazil

^[9] Clemente Estable Biol Res Inst, Mol & Genet Biol Div, Dept Mol Biol, Montevideo - Uruguay

^[10] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA - USA

^[11] Vitalant Res Inst, San Francisco, CA - USA

^[12] Fed Univ Para, Inst Biol Sci, Belem, Para - Brazil

^[13] Adolfo Lutz Inst, Enter Dis Lab, Virol Ctr, Ave Dr Arnaldo 355, BR-01246902 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: ARCHIVES OF VIROLOGY; v. 166, n. 3, p. 905-913, MAR 2021.
• Web of Science Citations: 3

Abstract

From 2010-2016, a total of 251 stool samples were screened for norovirus using next-generation sequencing (NGS) followed by phylogenetic analysis to investigate the genotypic diversity of noroviruses in rural and low-income urban areas in northern Brazil. Norovirus infection was detected in 19.9% (50/251) of the samples. Eight different genotypes were identified: GII.4\_Sydney{[}P31] (64%, 32/50), GII.6{[}P7] (14%, 7/50), GII.17{[}P17] (6%, 3/50), GII.1{[}P33] (6%, 3/50), GII.3{[}P16] (4%, 2/50), GII.2{[}P16] (2%, 1/50), GII.2{[}P2] (2%, 1/50), and GII.4\_New Orleans{[}P4] (2%, 1/50). Distinct GII.6{[}P7] variants were recognized, indicating the presence of different co-circulating strains. Elucidating norovirus genetic diversity will improve our understanding of their potential health burden, in particular for the GII.4\_Sydney{[}P31] variant. (AU)

• FAPESP's process: 17/00021-9 - Viral metagenomics to track, explain and predict the transmission and spatiotemporal spread of Dengue and Chikungunya viruses in Brazil
• Grantee: Antonio Charlys da Costa
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 15/12944-9 - Investigating the evoltution of animal rotavirus strains infecting humans
• Grantee: Adriana Luchs
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/01735-2 - Viral metagenomics to track, explain and predict the transmission and spatiotemporal spread of Dengue and Chikungunya viruses in Brazil
• Grantee: Ester Cerdeira Sabino
• Support Opportunities: Regular Research Grants
• FAPESP's process: 19/21706-5 - Viral metagenomics of mosquitoes captured in the State of São Paulo
• Grantee: Vanessa dos Santos Morais
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)