Electrochemical sensor for isoniazid detection by using a WS2/CNTs nanocomposite

Author(s)

Santos, Berlane G. ^[1] ; Goncalves, Josue M. ^[1] ; Rocha, Diego P. ^{[1, 2]} ; Higino, Giane S. ^[3] ; Yadav, Thakur P. ^[4] ; Pedrotti, Jairo J. ^[3] ; Ajayan, Pulickel M. ^[5] ; Angnes, Lucio ^[1]

Affiliation

^[1] Univ Sao Paulo, Dept Fundamental Chem, Inst Chem, Prof Lineu Prestes Ave 748, BR-05508000 Sao Paulo, SP - Brazil

^[2] Fed Inst Parana IFPR, Rua Jose de Alencar 1080, BR-85200000 Pitanga, PR - Brazil

^[3] Univ Prebiteriana Mackenzie, Engn Sch, Rua Consolacao 896, BR-01302907 Sao Paulo, SP - Brazil

^[4] Banaras Hindu Univ, Inst Sci, Dept Phys, Varanasi 221005, Uttar Pradesh - India

^[5] Rice Univ, Dept Mat Sci & Nanoengn, 6100 Main St, Houston, TX 77005 - USA

• Document type: Journal article
• Source: SENSORS AND ACTUATORS REPORTS; v. 4, NOV 2022.
• Web of Science Citations: 0

Abstract

This paper presents a new modified electrode that combines the high electrical conductivity of carbon nanotubes (CNTs) with the catalytic sites of WS2 (named WS2/CNTs) for isoniazid detection. Electrochemical and electroanalytical properties of the WS2/CNTs/glassy carbon electrode (GCE)-modified electrodes were investigated by cyclic voltammetry and differential pulse voltammetry (DPV). The composite material was characterized by Raman spectroscopy, X-ray diffractometry (XRD), and scanning electron microscopy . The electrochemical performance of the WS2/CNTs/GCE sensor exhibited a limit of detection of 0.24 mu M with a linear range from 10 to 80 mu M of isoniazid using DPV. This sensor provided enhanced stability and electrocatalytic activity for isoniazid oxidation reactions. Recoveries ranging from 96.9 to 104.5% were calculated, demonstrating satisfactory accuracy of the proposed method. The improvement of electrochemical activity was assigned to synergic effects obtained by combining the catalytic sites from WS2 and the known electrical conductivity and large surface area of the CNTs, resulting in an anticipation of the oxidation peak of isoniazid in about 400 mV in comparison with bare GCE. (AU)

• FAPESP's process: 19/22126-2 - Electrochemical behavior of carbonic acid hemiesters in aqueous medium
• Grantee: Berlane Gomes Santos
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 12/50259-8 - Graphene: photonics and opto-electronics: UPM-NUS collaboration
• Grantee: Antonio Helio de Castro Neto
• Support Opportunities: Research Projects - SPEC Program
• FAPESP's process: 18/16896-7 - Development of amperometric and impedimetric sensors based on double hydroxides of nickel and vanadium (alpha-NixV1-x(OH)2) and their nanocomposites with expandable graphite/graphene
• Grantee: Josué Martins Gonçalves
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 17/13137-5 - Formation and properties of hemiesters of carbonic acid in aqueous medium
• Grantee: Claudimir Lucio Do Lago
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis
• Grantee: Marco Aurelio Zezzi Arruda
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 20/00325-0 - Production of conductive filaments containing carbon nanomaterials and metal nanoparticles for the development of low cost enzymeless electrochemical biosensors via additive manufacturing
• Grantee: Diego Pessoa Rocha
• Support Opportunities: Scholarships in Brazil - Post-Doctoral