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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

etabolomics of the wild mushroom Gymnopilus imperialis (Agaricomycetes, Basidiomycota) by UHPLC-HRMS/MS analysis and molecular networ

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Author(s):
Caldas, Lhais A. [1] ; Soares, Douglas M. M. [2] ; Menolli, Nelson Jr Jr ; Stevani, V, Cassius ; Sartorelli, Patricia [1]
Total Authors: 5
Affiliation:
[1] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP - Brazil
[2] V, Univ Sao Paulo, Dept Quim Fundamental, Inst Quim, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: FUNGAL BIOLOGY; v. 126, n. 2, p. 132-138, FEB 2022.
Web of Science Citations: 0
Abstract

Gymnopilus consists in a widely distributed genus of mushroom-forming fungi, especially in tropical regions of the world. Literature on Gymnopilus representatives reports the presence of oligoisoprenoids, and styrylpyrones. Considering the large number of secondary metabolites that basidiomycetes might contain, dereplication tools such as GNPS (Global Natural Products Social Molecular Networking), has become important in prospecting metabolites, saving time and work on isolation and characterization of natural products. Thus, this work identified the wild mushroom Gymnopilus imperialis and dereplicated their extracts with the aid of GNPS to annotate oligoisoprenoids. It was possible to annotate 24 oligoisoprenoids from methanol, dichloromethaneand ethyl acetate extracts of G. imperialis, 4 of them from GNPS spectral library match, and 20 from prediction based on molecular network. Moreover HRMS-ESI( thorn ) dereplication of the acetate extract annotated bisnoryangonin and hispidin. To the best of our knowledge, this is the first report on the annotation of a series of gymnopilins analogues based on GNPS molecular network. Our findings suggest that GNPS might be an effective, rapid, and open-source device to identify compounds and predict analogues. (AU)

FAPESP's process: 18/15677-0 - Mushrooms in the Atlantic Forest: diversity and potential of edible species
Grantee:Nelson Menolli Junior
Support Opportunities: BIOTA-FAPESP Program - Young Investigators Grants
FAPESP's process: 17/22501-2 - Electronic chemiexcitation in biological systems: bioluminescence and photochemistry in the dark
Grantee:Etelvino José Henriques Bechara
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 16/24985-4 - Study the chemical composition of fungi and plants of the Atlantic Forest aimed at antitumor, antiparasitic and antimicrobial potential
Grantee:Patricia Sartorelli
Support Opportunities: Regular Research Grants
FAPESP's process: 19/12605-0 - Bioluminescence of Fungi, Millipede and Marine Organisms: Chemical and Biological Aspects
Grantee:Douglas Moraes Mendel Soares
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 18/25646-4 - Polysaccharides and special metabolites from basidiomycetes fungi: isolation, characterization and evaluation of antitumor potential
Grantee:Lhaís Araújo Caldas
Support Opportunities: Scholarships in Brazil - Doctorate