est Nile virus transmission potential in Portuga

Author(s):Show less -

Lourenco, Jose ^{[1, 2]} ; Barros, Silvia C. ^[3] ; Ze-ze, Libia ^{[2, 4]} ; Damineli, Daniel S. C. ^[5] ; Giovanetti, Marta ^{[6, 7]} ; Osorio, Hugo C. ^{[4, 8]} ; Amaro, Fatima ^{[4, 8]} ; Henriques, Ana M. ^[3] ; Ramos, Fernanda ^[3] ; Luis, Tiago ^[3] ; Duarte, Margarida D. ^[3] ; Fagulha, Teresa ^[3] ; Alves, Maria J. ^{[4, 8]} ; Obolski, Uri ^{[9, 10]}

Affiliation

^[1] Univ Oxford, Dept Zool, Oxford - England

^[2] Biosyst & Integrat Sci Inst, Edificio TecLabs, Campus FCUL, Lisbon - Portugal

^[3] Inst Nacl Invest Agr & Vet, Virol Lab, Oeiras - Portugal

^[4] Inst Nacl Saude Doutor Ricardo Jorge, Ctr Estudos Vectores & Doencas Infecc, Marateca - Portugal

^[5] Univ Sao Paulo, Dept Pediat, Fac Med, Sao Paulo - Brazil

^[6] Univ Fed Minas Gerais, Lab Genet Celular & Mol, Belo Horizonte, MG - Brazil

^[7] Inst Oswaldo Cruz Fiocruz, Lab Flavivirus, Rio De Janeiro - Brazil

^[8] Univ Lisbon, Inst Saude Ambiental, Fac Med, Lisbon - Portugal

^[9] Tel Aviv Univ, Sch Publ Hlth, Fac Med, Tel Aviv - Israel

^[10] Tel Aviv Univ, Porter Sch Environm & Earth Sci, Fac Exact Sci, Tel Aviv - Israel

• Document type: Journal article
• Source: COMMUNICATIONS BIOLOGY; v. 5, n. 1 JAN 10 2022.
• Web of Science Citations: 0

Abstract

Lourenco et al. review historical data and quantify the transmission potential of West Nile virus in Portugal. They report a North-South divide in infection patterns, a higher ecological capacity in the south, and an increasing positive effect of climate change over the last 40 years. It is unclear whether West Nile virus (WNV) circulates endemically in Portugal. Despite the country's adequate climate for transmission, Portugal has only reported four human WNV infections so far. We performed a review of WNV-related data (1966-2020), explored mosquito (2016-2019) and land type distributions (1992-2019), and used climate data (1981-2019) to estimate WNV transmission suitability in Portugal. Serological and molecular evidence of WNV circulation from animals and vectors was largely restricted to the south. Land type and climate-driven transmission suitability distributions, but not the distribution of WNV-capable vectors, were compatible with the North-South divide present in serological and molecular evidence of WNV circulation. Our study offers a comprehensive, data-informed perspective and review on the past epidemiology, surveillance and climate-driven transmission suitability of WNV in Portugal, highlighting the south as a subregion of importance. Given the recent WNV outbreaks across Europe, our results support a timely change towards local, active surveillance. (AU)

• FAPESP's process: 15/22308-2 - Intermediate representations in Computational Science for knowledge discovery
• Grantee: Roberto Marcondes Cesar Junior
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 19/23343-7 - Temporal analysis of gene expression
• Grantee: Daniel Santa Cruz Damineli
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 20/06160-3 - Human leukocyte transcriptional response to SARS-CoV-2 infection
• Grantee: Roberto Marcondes Cesar Junior
• Support Opportunities: Regular Research Grants