| Full text | |
| Author(s): |
Magalhaes Muniz, Maria Malane
;
Simielli Fonseca, Larissa Fernanda
;
dos Santos Silva, Danielly Beraldo
;
Braga Magalhaes, Ana Fabricia
;
Ferro, Jesus Aparecido
;
Loyola Chardulo, Luiz Artur
;
Baldi, Fernando
;
Canovas, Angela
;
de Albuquerque, Lucia Galvao
Total Authors: 9
|
| Document type: | Journal article |
| Source: | FUNCTIONAL & INTEGRATIVE GENOMICS; v. N/A, p. 16-pg., 2022-03-19. |
| Abstract | |
The aim of this study was to identify mRNA isoforms and small genetic variants that may be affecting marbling and beef color in Nellore cattle. Longissimus thoracic muscle samples from 20 bulls with different phenotypes (out of 80 bulls set) for marbling (moderate (n=10) and low (n=10) groups) and beef color (desirable (n=10) and undesirable (n = 9) group) traits were used to perform transcriptomic analysis using RNA sequencing. Fourteen and 15 mRNA isoforms were detected as differentially expressed (DE) (P-value <= 0.001) between divergent groups for marbling and meat color traits, respectively. Some of those DE mRNA isoforms have shown sites of splicing modified by small structural variants as single nucleotide variant (SNV), insertion, and/or deletion. Enrichment analysis identified metabolic pathways, such as O2/CO2 exchange in erythrocytes, tyrosine biosynthesis, and phenylalanine degradation. The results obtained suggest potential key regulatory genes associated with these economically important traits for the beef industry and for the consumer. (AU) | |
| FAPESP's process: | 09/16118-5 - Genomic tools to genetic improvement of direct economic important traits in Nelore cattle |
| Grantee: | Lucia Galvão de Albuquerque |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 17/10630-2 - Genetic aspects of meat production quality, efficiency and sustainability in Nelore breed animals |
| Grantee: | Lucia Galvão de Albuquerque |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/11154-2 - Identification of co-expression genes in Nellore cattle muscle tissue with divergent marbling and myofibrilar fragmentation index phenotypes, using RNA-Seq data |
| Grantee: | Maria Malane Magalhães Muniz |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| FAPESP's process: | 11/21241-0 - Study of the genetic variability of meat fatty acid profile in Nelore cattle finished in feedlot |
| Grantee: | Fernando Sebastián Baldi Rey |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 18/20026-8 - Multi-user equipment approved in grant 2017/10630-2: server |
| Grantee: | Lucia Galvão de Albuquerque |
| Support Opportunities: | Multi-user Equipment Program |