| Full text | |
| Author(s): Show less - |
Noronha, Natalia Yumi
;
Rodrigues, Guilherme da Silva
;
Yonehara Noma, Isabella Harumi
;
Cunha Brandao, Camila Fernanda
;
Rodrigues, Karine Pereira
;
Bruno, Alexandre Colello
;
Sae-Lee, Chanachai
;
Watanabe, Ligia Moriguchi
;
de Souza Pinhel, Marcela Augusta
;
Schineider, Isabelle Mello
;
de Almeida, Mariana Luciano
;
Junior, Fernando Barbosa
;
Morais, Deborah Araujo
;
de Sousa Junior, Wellington Tavares
;
Plosch, Torsten
;
Bueno Junior, Carlos Roberto
;
Nonino, Carla Barbosa
Total Authors: 17
|
| Document type: | Journal article |
| Source: | FRONTIERS IN ENDOCRINOLOGY; v. 13, p. 15-pg., 2022-08-15. |
| Abstract | |
BackgroundPre-diabetes precedes Diabetes Mellitus (DM) disease and is a critical period for hyperglycemia treatment, especially for menopausal women, considering all metabolic alterations due to hormonal changes. Recently, the literature has demonstrated the role of physical exercise in epigenetic reprogramming to modulate the gene expression patterns of metabolic conditions, such as hyperglycemia, and prevent DM development. In the present study, we hypothesized that physical exercise training could modify the epigenetic patterns of women with poor glycemic control. Methods48 post-menopause women aged 60.3 +/- 4.5 years were divided according to their fasting blood glucose levels into two groups: Prediabetes Group, PG (n=24), and Normal Glucose Group, NGG (n=24). All participants performed 14 weeks of physical exercise three times a week. The Infinium Methylation EPIC BeadChip measured the participants' Different Methylated Regions (DMRs). ResultsBefore the intervention, the PG group had 12 DMRs compared to NGG. After the intervention, five DMRs remained different. Interestingly, when comparing the PG group before and after training, 118 DMRs were found. The enrichment analysis revealed that the genes were related to different biological functions such as energy metabolism, cell differentiation, and tumor suppression. ConclusionPhysical exercise is a relevant alternative in treating hyperglycemia and preventing DM in post-menopause women with poor glycemic control. (AU) | |
| FAPESP's process: | 20/08687-9 - Selenium deficiency: identification of a risk profile considering genetic, clinical and environmental factors of patients with obesity in the pre and postoperative period of bariatric surgery |
| Grantee: | Lígia Moriguchi Watanabe |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 17/21361-2 - Global screening of genetic and epigenetic factors associated with magnitude of response to different physical training protocols in women 50-70 years |
| Grantee: | Carlos Roberto Bueno Júnior |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/24069-3 - ReSEARCH: Recognizing Signatures of the Exposome to Anticipate the Risks for a Continuous Health |
| Grantee: | Fernando Barbosa Júnior |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 14/16740-6 - Expressão de genes relacionados ao gasto energético e metabolismo de lipídios de indivíduos com obesidade grau III antes e após intervenções para perda de peso |
| Grantee: | Natália Yumi Noronha |
| Support Opportunities: | Scholarships in Brazil - Technical Training Program - Technical Training |