A Review of Omics Studies on Arboviruses: Alphavirus, Orthobunyavirus and Phlebovirus

Author(s)

Peinado, Rafaela dos S. ; Eberle, Raphael J. ; Arni, Raghuvir K. ; Coronado, Monika A.

• Document type: Journal article
• Source: Viruses-Basel; v. 14, n. 10, p. 28-pg., 2022-10-01.

Abstract

Since the intricate and complex steps in pathogenesis and host-viral interactions of arthropod-borne viruses or arboviruses are not completely understood, the multi-omics approaches, which encompass proteomics, transcriptomics, genomics and metabolomics network analysis, are of great importance. We have reviewed the omics studies on mosquito-borne viruses of the Togaviridae, Peribuyaviridae and Phenuiviridae families, specifically for Chikungunya, Mayaro, Oropouche and Rift Valley Fever viruses. Omics studies can potentially provide a new perspective on the pathophysiology of arboviruses, contributing to a better comprehension of these diseases and their effects and, hence, provide novel insights for the development of new antiviral drugs or therapies. (AU)

• FAPESP's process: 20/08615-8 - Protein exosites, cryptic sites and moonlighting: identification, functional mapping and effects of changes in structure
• Grantee: Raghuvir Krishnaswamy Arni
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 20/03639-6 - NMR metabolomics: metabolomic profiles of Vero cells infected with Zika and Chikungunya and inhibition by wedelolactone
• Grantee: Rafaela dos Santos Peinado
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)