Assessment of Renal Function in Head and Neck Cancer Patients Treated with Cisplatin: Different Biomarkers and Acute Kidney Injury Classifications

Author(s)

de Godoy Torso, Nadine ; Visacri, Marilia Berlofa ; Quintanilha, Julia Coelho Franca ; Cursino, Maria Aparecida ; Pincinato, Eder de Carvalho ; Moriel, Patricia

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 24, n. 1, p. 18-pg., 2023-01-01.

Abstract

Cisplatin is associated with dose-limiting nephrotoxicity, and the timely detection of acute kidney injury (AKI) can affect morbimortality. Therefore, this study aimed to investigate the tools for monitoring renal function in AKI. This was a retrospective, cohort study. Cisplatin-treated patients with head and neck cancer were included. Nephrotoxicity was assessed using serum creatinine, estimated creatinine clearance, serum electrolytic alterations, and plasma kidney injury molecule-1 (KIM-1). The toxicity severity was classified according to Common Terminology Criteria for Adverse Events (CTCAE), and AKI was classified by Risk, Injury, Failure, Loss, and End-stage kidney disease (RIFLE) and Acute Kidney Injury Network (AKIN). A total of 81 participants were included, of whom only 32 did not have AKI. Almost 90% of participants had a decreased estimated glomerular filtration rate five (D5) days after chemotherapy. The AKI estimate differs between AKIN and RIFLE; more participants were diagnosed by the RIFLE at D5, 19.5% versus 2.4% by AKIN, and fifteen had a discordance between these classifications. All laboratory markers showed significant changes on D5. KIM-1 appeared a possible biomarker when considering CTCAE or AKIN classifications (p < 0.05 on D5), but not when RIFLE classification was used (p = 0.0780). Further studies may seek to understand the profiles of different biomarkers together. (AU)

• FAPESP's process: 19/20010-7 - MicroRNAs as possible cypplin-induced nephrotoxicity predictors in head and neck cancer patients
• Grantee: Nadine de Godoy Torso
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 17/17245-7 - Polymorphism analysis of the CYP2E1, ABCB1, ABCC2, OCT2 and MATE1 genes involved in the major adverse effects of cisplatin treatment of the Head and Neck Cancer
• Grantee: Maria Aparecida Cursino
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/02338-0 - MicroRNAs and oxidated molecules as possible biomarkers of cisplatin-induced nephrotoxicity in patients with head and neck cancer
• Grantee: Júlia Coelho França Quintanilha
• Support Opportunities: Scholarships in Brazil - Doctorate