| Full text | |
| Author(s): |
Sposito, Heitor Gabriel Martins
;
Lobato, Alnilan
;
Tasic, Nikola O.
;
Maldaner, Adriano O.
;
Paixao, Thiago R. L. C.
;
Goncalves, Luis Moreira
Total Authors: 6
|
| Document type: | Journal article |
| Source: | JOURNAL OF ELECTROANALYTICAL CHEMISTRY; v. 911, p. 7-pg., 2022-03-11. |
| Abstract | |
Diltiazem is a calcium channel-blocking agent, efficient in treating various heart-related conditions and dis-eases. It has been used as a cutting agent in cocaine and prevents its common cardiotoxic effects. This paper presents a highly selective molecularly-imprinted sensor to detect diltiazem in buffer and urine. In addition, the possibility of using this sensor as a forensic tool for fingerprinting street-seized cocaine samples of hetero-geneous composition was investigated. With thorough optimization of the fabrication process, it was possible to obtain a sensible and reproducible analytical signal via square-wave voltammetry (SWV) as the electroana-lytical technique. The obtained analytical parameters for the samples in buffer, pH 7.4, were the limit of detec-tion (LOD) of 0.12 mu mol L-1, the limit of quantification (LOQ) of 0.41 mu mol L-1, and inter-day reproducibility of 2%. For the samples in artificial urine, the analytical parameters were LOD of 0.26 mu mol L-1, LOQ of 0.88 mu mol L-1, and inter-day reproducibility of 9%. Decent linearity of the analytical signal with the increased concentration of diltiazem in the cocaine street samples suggested a high perspective of the proposed sensor for the forensic laboratory applications, more precisely, the determination of the seized samples' origins. (AU) | |
| FAPESP's process: | 18/13922-7 - Development of a point-of-care biosensor for the swift determination of D-Dimers |
| Grantee: | Nikola Tasic |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 18/14425-7 - A new synergetic path for gas-diffusion microextraction (GDME) making use of molecular imprinted polymers (MIPs) |
| Grantee: | Luís Francisco Moreira Gonçalves |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 19/16491-0 - Rapid, onsite detection of toxic metals combining paper-based electrochemical sensors and fast-scan cyclic voltammetry |
| Grantee: | Thiago Regis Longo Cesar da Paixão |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 19/11214-8 - Application of capillary electrophoresis for the determination of aldehydes after extraction by GDME-MIPs |
| Grantee: | Alnilan Cristina Barros Lobato |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 17/10522-5 - Development of alternative methods for fabrication of electrochemical paper-based sensors |
| Grantee: | Thiago Regis Longo Cesar da Paixão |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/08782-1 - Miniaturized and integrated chemical sensors: new fabrication platforms for biological, clinical and environmental applications |
| Grantee: | Mauro Bertotti |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 20/04268-1 - Electroanalytical determination of calcium channel blockers making use of molecularly imprinted polymers |
| Grantee: | Heitor Gabriel Martins Sposito |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |