Violaceae: chemical constituents, traditional use and pharmacology

Author(s)

Fernandez-Bobey, Antonio ; Dias, Nathalia Baptista ; Vieira, Natalia Carolina ; Zanatta, Ana C. ; de Souza, Bibiana Monson ; de Paula-Souza, Juliana ; da Silva Bolzani, Vanderlan ; Palma, Mario Sergio

• Document type: Journal article
• Source: PHYTOCHEMISTRY REVIEWS; v. N/A, p. 81-pg., 2023-07-19.

Abstract

Species of the Violaceae family, especially those of the genus Viola, are widely used in traditional medicine to treat various diseases. Their use is due to a large number of secondary metabolites present in plants of this family that present anticancer, antioxidant, antibacterial, anti-inflammatory, antiviral, insecticidal and cytotoxic activities, among other properties. This review describes the chemical constituents, traditional uses and biological activities reported for the Violaceae family to date. The literature reports seven hundred and sixty-two secondary metabolites in the Violaceae family, which were classified into seven specific organic functional classes (flavonoids, terpenoids, sterols, alkaloids, phenylpropanoids, essential oils, cyclotide peptides), and one nonspecific class (miscellaneous compounds). This review presents the chemical structures, names, and corresponding plant sources of these compounds along with their biological activities. The rich profile of biologically active compounds isolated from Violaceae species might be a valuable resource for inspiring the rational development of novel therapeutic drugs. (AU)

• FAPESP's process: 19/18673-8 - Metabolomic study of Brazilian plants used in the treatment of chronic diseases
• Grantee: Ana Caroline Zanatta Silva
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
• Grantee: Glaucius Oliva
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 16/21044-4 - Standardization of phytomedicines for the treatment of chronic diseases
• Grantee: Ana Caroline Zanatta Silva
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/26550-3 - Cyclic peptides from brazilian plants: isolation, structural characterization, synthesis, and evaluation of biological activities
• Grantee: Antonio Fernández Bobey
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 16/16212-5 - Natural proteopeptides from the Brazilian fauna, flora and microbiota as potential models for the rational development of new drugs of therapeutic use: isolation, structure elucidation, chemical synthesis and functional activity assays
• Grantee: Mario Sergio Palma
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
• FAPESP's process: 14/50926-0 - INCT 2014: biodiversity and natural products
• Grantee: Vanderlan da Silva Bolzani
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants