Biomaterial engineering surface to control polymicrobial dental implant-related infections: focusing on disease modulating factors and coatings development

Author(s)

Malheiros, Samuel S. ; Nagay, Bruna E. ; Bertolini, Martinna M. ; de Avila, Erica D. ; Shibli, Jamil A. ; Souza, Joao Gabriel S. ; Barao, Valentim A. R.

• Document type: Journal article
• Source: Expert Review of Medical Devices; v. 20, n. 7, p. 17-pg., 2023-05-31.

Abstract

IntroductionPeri-implantitis is the leading cause of dental implant loss and is initiated by a polymicrobial dysbiotic biofilm formation on the implant surface. The destruction of peri-implant tissue by the host immune response and the low effectiveness of surgical or non-surgical treatments highlight the need for new strategies to prevent, modulate and/or eliminate biofilm formation on the implant surface. Currently, several surface modifications have been proposed using biomolecules, ions, antimicrobial agents, and topography alterations.Areas coveredInitially, this review provides an overview of the etiopathogenesis and host- and material-dependent modulating factors of peri-implant disease. In addition, a critical discussion about the antimicrobial surface modification mechanisms and techniques employed to modify the titanium implant material is provided. Finally, we also considered the future perspectives on the development of antimicrobial surfaces to narrow the bridge between idea and product and favor the clinical application possibility.Expert opinionAntimicrobial surface modifications have demonstrated effective results; however, there is no consensus about the best modification strategy and in-depth information on the safety and longevity of the antimicrobial effect. Modified surfaces display recurring challenges such as short-term effectiveness, the burst release of drugs, cytotoxicity, and lack of reusability. Stimulus-responsive surfaces seem to be a promising strategy for a controlled and precise antimicrobial effect, and future research should focus on this technology and study it from models that better mimic clinical conditions. (AU)

• FAPESP's process: 21/09434-0 - A novel antimicrobial drug-delivery coating for percutaneous implant devices
• Grantee: Érica Dorigatti de Avila
• Support Opportunities: Scholarships in Brazil - Young Researchers
• FAPESP's process: 22/15677-5 - Synthesis of a bilayer coating functionalized with zinc and photoactivated chitosan-antibiotic complex for controlled drug release in dental implants
• Grantee: Samuel Santana Malheiros
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 20/05231-4 - Development of a new thermosensitive hydrogel for controlled release of drugs to prevent and treat peri-implant inflammations
• Grantee: Valentim Adelino Ricardo Barão
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/20719-3 - A novel antimicrobial drug-delivery coating for percutaneous implant devices
• Grantee: Érica Dorigatti de Avila
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 19/17238-6 - Antibacterial coating with photocatalytic potential under visible light for dental implants: in vitro, in situ and in vivo studies
• Grantee: Bruna Egumi Nagay
• Support Opportunities: Scholarships in Brazil - Doctorate