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Modification of the physicochemical properties with different coating materials of titanium implant abutment surfaces and evaluation of their effects on the development of a polymicrobial community representative of the oral cavity: an in vitro preliminar

Grant number: 15/03567-7
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): August 01, 2015
Effective date (End): December 01, 2019
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Carlos Eduardo Vergani
Grantee:Érica Dorigatti de Avila
Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated research grant:13/07296-2 - CDMF - Center for the Development of Functional Materials, AP.CEPID
Associated scholarship(s):16/19650-3 - Functional layer-by-layer coatings for implant abutment surfaces: investigating the effect of controlled release of antibacterial agents on cytokine signaling and production of inflammatory mediators induced by Porphyromonas gingivalis LPS, BE.EP.PD


In the last decades, the dental implants treatment has become an efficient method of treatment for patients, to replace missed teeth. Subsequently, with advancing of the implant therapy, the number of complications that arise over time is on the increase at clinics. Biofilm development around the implants is thought to be the most important responsible to late failure implants. Since that bacterial colonization of the surfaces starts after their exposure to the oral environment, abutment has a pertinent clinical interest due to its supra and subgingival localization and intimate contact of these substrates with the peri-implantar tissue. While traditional studies concentrate in methods to change dental implants surfaces to improve the osseointegration process, we are proposing to develop a new coating to titanium abutments, focusing in inhibiting the bacteria growth to prevent the peri implantitis disease. To this end, our purpose is to modify the physiochemical properties of titanium materials with different types of coating, and evaluate its effect on the development of a cultivable polymicrobial community representative of the oral cavity in combination with a bacterial growth medium (SHI-FSMS) containing saliva and blood components, as model system for bacterial attachment and biofilm formation. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALVES DA SILVA PIMENTEL, BRUNA NATALIA; DE FOGGI, CAMILA CRISTINA; BARBUGLI, PAULA ABOUD; DE OLIVEIRA, REGIANE CRISTINA; DE AVILA, ERICA DORIGATTI; LONGO, ELSON; VERGANI, CARLOS EDUARDO. Antifungal activity and biocompatibility of alpha-AgVO3 microcrystals: A promising material against oral Candida disease. Materials Science & Engineering C-Materials for Biological Applications, v. 108, . (15/25124-0, 15/13834-2, 13/07296-2, 15/03654-7, 15/03567-7)
DE AVILA, ERICA D.; CASTRO, ANTONIO G. B.; TAGIT, OYA; KROM, BASTIAAN P.; LOWIK, DENNIS; VAN WELL, AD A.; BANNENBERG, LARS J.; VERGANI, CARLOS EDUARDO; VAN DEN BEUCKEN, JEROEN J. J. P.. Anti-bacterial efficacy via drug-delivery system from layer-by-layer coating for percutaneous dental implant components. Applied Surface Science, v. 488, p. 194-204, . (15/03567-7, 16/19650-3)
HARO CHAVEZ, NATALI LISETTE; DE AVILA, ERICA DORIGATTI; BARBUGLI, PAULA ABOUD; DE OLIVEIRA, REGIANE CRISTINA; DE FOGGI, CAMILA CRISTINA; LONGO, ELSON; VERGANI, CARLOS EDUARDO. Promising effects of silver tungstate microcrystals on fibroblast human cells and three dimensional collagen matrix models: A novel non-cytotoxic material to fight oral disease. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 170, p. 505-513, . (15/25124-0, 13/07296-2, 15/03654-7, 15/03567-7)
DE AVILA, ERICA D.; VAN OIRSCHOT, BART A.; VAN DEN BEUCKEN, JEROEN J. J. P.. Biomaterial-based possibilities for managing peri-implantitis. JOURNAL OF PERIODONTAL RESEARCH, . (15/03567-7, 16/19650-3)
VAN OIRSCHOT, BART A. J. A.; ZHANG, YANG; ALGHAMDI, HAMDAN S.; CORDEIRO, JAIRO M.; NAGAY, BRUNA E.; BARAO, VALENTIM A. R.; DE AVILA, ERICA DORIGATTI; VAN DEN BEUCKEN, JEROEN J. J. P.. Surface Engineering for Dental Implantology: Favoring Tissue Responses Along the Implant. TISSUE ENGINEERING PART A, v. 28, n. 11-12, p. 18-pg., . (20/05231-4, 18/20719-3, 21/09434-0, 19/17238-6, 17/01320-0, 15/03567-7)

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