Advances in green extraction methods, biological properties, and applications of betanin and vitexin: An updated review and bibliometric analysis

Author(s)

Marinho, Leonardo de Freitas ; Sganzerla, William Gustavo ; Ferreira, Vanessa Cosme ; Moreno, Juver Andrey Jimenez ; Rostagno, Mauricio Ariel ; Forster-Carneiro, Tania

• Document type: Journal article
• Source: BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY; v. 51, p. 17-pg., 2023-08-01.

Abstract

This systematic review and bibliometric analysis investigated the research gaps, trends, and updates in the recovery and applications of betanin and vitexin, focusing on describing the sustainable extraction methods and biological properties. The bibliometric analysis revealed considerable growth in publications in the last two years. The keywords network analysis demonstrated that antioxidant activity, betalain, betanin, and betacyanin are the main research clusters, highlighting that the recovery of vitexin from by-products is a potential theme for investigation. The demand for betanin and vitexin has been increasing in the last years, mainly due to the beneficial biological properties (anti-inflammatory, antioxidant, antimicrobial, and anticancer activity) and pharmaceutical applications for replacing synthetic drugs in the development of nutraceutical food products. Hence, the application of ultrasound-assisted extraction, pulsed electric field extraction, pressurized liquid extraction, and subcritical water extraction are the sustainable extraction methods most suitable for the recovery of betanin and vitexin, which support the application in the food, pharmaceutical, and health industries. (AU)

• FAPESP's process: 19/26925-7 - Development of an automated system for biofuel precursor production using sub-critical technology
• Grantee: William Gustavo Sganzerla
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 22/11690-7 - EVALUATION OF BETANIN EXTRACTION IN BEET LEAVES (BETA VULGARIS L.) USING SUBCRITICAL WATER IN AUTOMATED REACTOR WITH IN-LINE ANALYSIS
• Grantee: Leonardo de Freitas Marinho
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 22/02305-2 - Evaluation of subcritical water hydrolysis in an automated reactor with in-line analysis of compounds with higher added value from pitaya peels (Hylocereus undatus)
• Grantee: Vanessa Cosme Ferreira
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 18/14938-4 - Waste2energy: integration of supercritical technologies and anaerobic digestion through an automated system for the production of biofuel precursors
• Grantee: Tânia Forster Carneiro
• Support Opportunities: Research Grants - Young Investigators Grants - Phase 2