Polyketide- and Terpenoid-Derived Metabolites Produced by a Marine-Derived Fungus, Peroneutypa sp.

Author(s):Show less -

de Amorim, Marcelo R. ; Barbosa, Camila de S. ; Paz, Tiago A. ; Ioca, Laura P. ; Nicacio, Karen J. ; de Oliveira, Lucianne F. P. ; Goulart, Mirian O. ; Paulino, Julia M. ; da Cruz, Mateus O. ; Ferreira, Antonio G. ; Furlan, Maysa ; de Lira, Simone P. ; dos Santos, Raquel A. ; Rodrigues, Andre ; Guido, Rafael V. C. ; Berlinck, Roberto G. S.

• Document type: Journal article
• Source: Journal of Natural Products; v. 86, n. 6, p. 11-pg., 2023-06-08.

Abstract

Bioassay-guided investigation of the EtOAc-soluble extractof aculture of the marine-derived fungus Peroneutypa sp.M16 led to the isolation of seven new polyketide- and terpenoid-derivedmetabolites (1, 2, 4-8), along with known polyketides (3, 9-13). Structures of compounds 1, 2, and 4-8 were establishedby analysis of spectroscopic data. Absolute configurations of compounds 1, 2, 4, 6, 7, and 8 were determined by the comparison of experimentalECD spectra with calculated CD data. Compound 5 exhibitedmoderate antiplasmodial activity against both chloroquine-sensitiveand -resistant strains of Plasmodium falciparum. (AU)

• FAPESP's process: 19/17721-9 - The role of Chemistry in holobiont adaptation
• Grantee: Roberto Gomes de Souza Berlinck
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 16/05133-7 - Study of marine-derived microrganisms metabolism: chemical profile and biosynthesis
• Grantee: Laura Pavan Ióca
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 15/01017-0 - Multi-use instrument approved and awarded in the project 2013/50228-8, name of instrument: ultra-performance liquid chromatograph coupled with a high resolution mass spectrometer
• Grantee: Roberto Gomes de Souza Berlinck
• Support Opportunities: Multi-user Equipment Program
• FAPESP's process: 20/12904-5 - Discovery of Plasmodium falciparum inhibitors from Cerrado plants as lead compounds candidates for malaria: integrated studies of ultra-efficient chromatography, spectroscopy, and biological assays
• Grantee: Rafael Victorio Carvalho Guido
• Support Opportunities: BIOTA-FAPESP Program - Regular Research Grants
• FAPESP's process: 20/01229-5 - Bioactive metabolites of bacterial flora microorganisms from non-filtering marine animals
• Grantee: Marcelo Rodrigues de Amorim
• Support Opportunities: Scholarships in Brazil - Post-Doctoral