| Full text | |
| Author(s): |
Pedrosa, Lucas de Freitas
;
Nascimento, Karen Reboucas
;
Soares, Caroline Giacomelli
;
de Oliveira, Debora Preceliano
;
de Vos, Paul
;
Fabi, Joao Paulo
Total Authors: 6
|
| Document type: | Journal article |
| Source: | PLANTS-BASEL; v. 12, n. 14, p. 21-pg., 2023-07-01. |
| Abstract | |
Pectin, a plant-derived polysaccharide, possesses immense technological and biological application value. Several variables influence pectin's physicochemical aspects, resulting in different fermentations, interactions with receptors, and other functional properties. Some of those variables are molecular weight, degree of methylation and blockiness, and monosaccharide composition. Cancer cell cytotoxicity, important fermentation-related byproducts, immunomodulation, and technological application were found in cell culture, animal models, and preclinical and clinical assessments. One of the greater extents of recent pectin technological usage involves nanoencapsulation methods for many different compounds, ranging from chemotherapy and immunotherapy to natural extracts from fruits and other sources. Structural modification (modified pectin) is also utilized to enhance the use of dietary fiber. Although pectin is already recognized as a component of significant importance, there is still a need for a comprehensive review that delves into its intricate relationships with biological effects, which depend on the source and structure of pectin. This review covers all levels of clinical research, including cell culture, animal studies, and clinical trials, to understand how the plant source and pectin structures influence the biological effects in humans and some technological applications of pectin regarding human health. (AU) | |
| FAPESP's process: | 22/12834-2 - Effects of modified pectins on gut health: pre-clinical and clinical studies to assess cellular, transcriptional, and epigenetic effects |
| Grantee: | Joao Paulo Fabi |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 20/08063-5 - Study of the biological effects of modified passion fruit pectins using in vitro and in vivo models of Colon Carcinogenesis |
| Grantee: | Lucas de Freitas Pedrosa |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 22/12253-0 - In vitro study of human intestinal integrity and TLR modulation after modified passion fruit pectin treatment |
| Grantee: | Lucas de Freitas Pedrosa |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate (Direct) |
| FAPESP's process: | 13/07914-8 - FoRC - Food Research Center |
| Grantee: | Bernadette Dora Gombossy de Melo Franco |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |