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Flexible and sustainable printed sensor strips for on-site, fast decentralized self-testing of urinary biomarkers integrated with a portable wireless analyzer

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Author(s):
Gomes, Nathalia O. ; Teixeira, Samiris Cocco ; Calegaro, Marcelo L. ; Machado, Sergio A. S. ; Ferreira Soares, Nilda de Fatima ; de Oliveira, Taila Veloso ; Raymundo-Pereira, Paulo A.
Total Authors: 7
Document type: Journal article
Source: CHEMICAL ENGINEERING JOURNAL; v. 472, p. 10-pg., 2023-09-15.
Abstract

Flexible and sustainable electronic devices may fulfill the requirements of Sustainable Development Goals (SDGs) contained in Agenda 2030 from United Nations, however, the use of degradable and eco-friendly devices for rapid, selective and on-site decentralized monitoring of patient health status with portable systems toward diagnosis, fast decision and medical interventions is relatively new. Herein, we introduce flexible and sustainable substrates/support of degradable bio-based PLA films from renewable resources produced by casting method as a sustainable alternative to conventional petroleum-based plastics toward portable electronic devices and sensing applications. The flexible devices containing full electrochemical sensing system were built with screen-printing process on PLA sustainable substrates for on-site, rapid decentralized monitoring of molecular biomarkers in noninvasive sample. Reliable urinary dopamine and uric acid analysis with limit of detections of 0.138 & mu;M and 0.595 & mu;M could be performed with low-cost sustainable devices (<US$ 0.08 per unit) in undiluted human urine using a flexible sensor strip coupled with a Sensit BT portable analyzer connected via Bluetooth to a smartphone, laptop or tablet. The flexible eco-friendly sensor was highly robust against severe bending strains, reproducible and selective without interference from other compounds in human urine. The sustainable sensor response was fast within 3 min with an analytical performance comparable to the gold standard method. (AU)

FAPESP's process: 23/07686-7 - Design and fabrication of disposable electrochemical devices based on carbon spherical shells doped with nitrogen and decorated with carbon quantum dots for the detection of pesticides in water supply samples
Grantee:Nathalia Oezau Gomes
Support Opportunities: Scholarships in Brazil - Technical Training Program - Technical Training
FAPESP's process: 19/01777-5 - Manufacture of disposable electrochemical devices composed of hollow carbon nanospheres and carbon nanowires decorated with silver nanoparticles for the quantification of endocrine disruptors in supply water samples
Grantee:Sergio Antonio Spinola Machado
Support Opportunities: Regular Research Grants
FAPESP's process: 22/02164-0 - Development of electrochemical sensors modified with hollow carbon nanospheres doped with sulfur and nitrogen for the quantification of drugs in supply water samples
Grantee:Sergio Antonio Spinola Machado
Support Opportunities: Regular Research Grants
FAPESP's process: 23/00850-6 - Development of nanostructured biosensors for the diagnosis of mental disorders biomarkers
Grantee:Osvaldo Novais de Oliveira Junior
Support Opportunities: Regular Research Grants
FAPESP's process: 16/01919-6 - Design and fabrication of nanostructured flexible devices for biomarkers detection
Grantee:Paulo Augusto Raymundo Pereira
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 20/09587-8 - Development of electrochemical devices based on carbon and silver nanostructures to detect endocrine disruptors in quantities of water supply
Grantee:Nathalia Oezau Gomes
Support Opportunities: Scholarships in Brazil - Doctorate