Plant-derived polyphenolic compounds: nanodelivery through polysaccharide-based systems to improve the biological properties

Author(s)

Rosales, Thiecla Katiane Osvaldt ; da Silva, Fabio Fernando Alves ; Bernardes, Emerson Soares ; Fabi, Joao Paulo

• Document type: Journal article
• Source: CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION; v. N/A, p. 25-pg., 2023-08-04.

Abstract

Plant-derived polyphenols are naturally occurring compounds widely distributed in plants. They have received greater attention in the food and pharmaceutical industries due to their potential health benefits, reducing the risk of some chronic diseases due to their antioxidant, anti-inflammatory, anticancer, cardioprotective, and neuro-action properties. Polyphenolic compounds orally administered can be used as adjuvants in several treatments but with restricted uses due to chemical instability. The review discusses the different structural compositions of polyphenols and their influence on chemical stability. Despite the potential and wide applications, there is a need to improve the delivery of polyphenolics to target the human intestine without massive chemical modifications. Oral administration of polyphenols is unfeasible due to instability, low bioaccessibility, and limited bioavailability. Nano-delivery systems based on polysaccharides (starch, pectin, chitosan, and cellulose) have been identified as a viable option for oral ingestion, potentiate biological effects, and direct-controlled delivery in specific tissues. The time and dose can be individualized for specific diseases, such as intestinal cancer. This review will address the mechanisms by which polysaccharides-based nanostructured systems can protect against degradation and enhance intestinal permeation, oral bioavailability, and the potential application of polysaccharides as nanocarriers for the controlled and targeted delivery of polyphenolic compounds. (AU)

• FAPESP's process: 22/12834-2 - Effects of modified pectins on gut health: pre-clinical and clinical studies to assess cellular, transcriptional, and epigenetic effects
• Grantee: Joao Paulo Fabi
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/07914-8 - FoRC - Food Research Center
• Grantee: Bernadette Dora Gombossy de Melo Franco
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 23/09620-3 - Nanocarriers of Pectin and Lysozyme-Based Anthocyanins: Experimental Approach to Assess Increased Bioavailability and Anticancer Effects in the Colon of Rats
• Grantee: Thiécla Katiane Osvaldt Rosales
• Support Opportunities: Scholarships in Brazil - Support Program for Fixating Young Doctors
• FAPESP's process: 23/01396-7 - Pectin and Lysozyme-Based Anthocyanin Nanocarriers: Experimental Approach to Assess Bioavailability Improvement and Anticancer Effects in the Colon of Rats
• Grantee: Joao Paulo Fabi
• Support Opportunities: Regular Research Grants