Biocompatible anti-aging face mask prepared with curcumin and natural rubber with antioxidant properties

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Silva, Flavio Kunert de Souza ; Costa-Orlandi, Caroline Barcelos ; Fernandes, Mariza Aires ; Brasil, Giovana Sant'Ana Pegorin ; Mussagy, Cassamo Ussemane ; Scontri, Mateus ; Sasaki, Josana Carla da Silva ; Abreu, Ana Paula de Sousa ; Guerra, Nayrim Brizuela ; Floriano, Juliana Ferreira ; de Mendonca, Ricardo Jose ; Caetano, Guilherme Ferreira ; Farhadi, Neda ; Gomez, Alejandro ; Huang, Shuyi ; Farias, Andressa Machado ; Primo, Fernando Lucas ; Li, Bingbing ; Fusco-Almeida, Ana Marisa ; Dokmeci, Mehmet Remzi ; Jucaud, Vadim ; Mendes-Giannini, Maria Jose Soares ; Cardoso, Marcos Roberto ; Herculano, Rondinelli Donizetti

• Document type: Journal article
• Source: International Journal of Biological Macromolecules; v. 242, p. 12-pg., 2023-05-13.

Abstract

Natural rubber latex (NRL) is a biopolymer widely used in biomedical applications. In this work, we propose an innovative cosmetic face mask, combining the NRL's biological properties with curcumin (CURC), which has a high level of antioxidant activity (AA) to provide anti-aging benefits. Chemical, mechanical and morphological characterizations were performed. The CURC released by the NRL was evaluated by permeation in Franz cells. Cytotoxicity and hemolytic activity assays were performed to assess safety. The findings showed that the bio-logical properties of CURC were preserved after loading in the NRL. About 44.2 % of CURC was released within the first six hours, and in vitro permeation showed that 9.36 % +/- 0.65 was permeated over 24 h. CURC-NRL was associated with a metabolic activity higher than 70 % in 3 T3 fibroblasts, cell viability >= 95 % in human dermal fibroblasts, and a hemolytic rate <= 2.24 % after 24 h. Furthermore, CURC-NRL maintained the mechanical characteristics (range suitable) for human skin application. We observed that CURC-NRL preserved similar to 20 % antioxidant activity from curcumin-free after loading in the NRL. Our results suggest that CURC-NRL has the potential to be used in the cosmetics industry, and the experimental methodology utilized in this study can be applied to different kinds of face masks. (AU)

• FAPESP's process: 18/07342-8 - Development of microfluidic devices/organ on a chip using xurography, poliester-toner and gelatin methacryloyl (GelMA)
• Grantee: Rondinelli Donizetti Herculano
• Support Opportunities: Scholarships abroad - Research
• FAPESP's process: 17/19603-8 - Development of a novel patch containing latex and barbatimam e fractions and study of signaling pathways in cutaneous wound repair
• Grantee: Rondinelli Donizetti Herculano
• Support Opportunities: Regular Research Grants
• FAPESP's process: 21/09207-3 - Fabrication of electrochemical transistors based on doped melanin with improved ionic and electronic conductivity
• Grantee: Nayrim Brizuela Guerra
• Support Opportunities: Scholarships in Brazil - Post-Doctoral