Ciprofloxacin Release Using Natural Rubber Latex Membranes as Carrier

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Murbach, Heitor Dias ; Ogawa, Guilherme Jaques ; Borges, Felipe Azevedo ; Romeiro Miranda, Matheus Carlos ; Lopes, Rute ; de Barros, Natan Roberto ; Guedes Mazalli, Alexandre Vinicius ; da Silva, Rosngela Goncalves ; Ferreira Cinman, Jose Luiz ; Drago, Bruno de Camargo ; Herculano, Rondinelli Donizetti

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF BIOMATERIALS; v. 2014, p. 7-pg., 2014-01-01.

Abstract

Natural rubber latex (NRL) from Hevea brasiliensis is easily manipulated, low cost, is of can stimulate natural angiogenesis and cellular adhesion, is a biocompatible, material and presents high mechanical resistance. Ciprofloxacin (CIP) is a synthetic antibiotic (fluoroquinolone) used in the treatment of infection at external fixation screws sites and remote infections, and this use is increasingly frequent in medical practice. The aim of this study was to develop a novel sustained delivery system for CIP based on NRL membranes and to study its delivery system behavior. CIP was found to be adsorbed on the NRL membrane, according to results of energy dispersive X-ray spectroscopy. Results show that the membrane can release CIP for up to 59.08% in 312 hours and the mechanism is due to super case II (non-Fickian). The kinetics of the drug release could be fitted with double exponential function X-ray diffraction and Fourier transform infrared (FTIR) spectroscopy shows some interaction by hydrogen bound, which influences its mechanical behavior. (AU)

• FAPESP's process: 11/17411-8 - Evaluation of drugs delivery systems using natural rubber latex membranes as carrier
• Grantee: Rondinelli Donizetti Herculano
• Support Opportunities: Regular Research Grants