Biotech-Educated Platelets: Beyond Tissue Regeneration 2.0

Author(s)

Andrade, Sheila Siqueira ; de Sousa Faria, Alessandra Valeria ; Girao, Manoel Joao Batista C. ; Fuhler, Gwenny M. ; Peppelenbosch, Maikel P. ; Ferreira-Halder, Carmen, V

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 21, n. 17, p. 14-pg., 2020-09-01.

Abstract

The increasing discoveries regarding the biology and functions of platelets in the last decade undoubtedly show that these cells are one of the most biotechnological human cells. This review summarizes new advances in platelet biology, functions, and new concepts of biotech-educated platelets that connect advanced biomimetic science to platelet-based additive manufacturing for tissue regeneration. As highly responsive and secretory cells, platelets could be explored to develop solutions that alter injured microenvironments through platelet-based synthetic biomaterials with instructive extracellular cues for morphogenesis in tissue engineering beyond tissue regeneration 2.0. (AU)

• FAPESP's process: 15/20412-7 - Low molecular weight protein tyrosine phosphatase in colorectal cancer: from the bench to product generation
• Grantee: Carmen Veríssima Ferreira
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 16/14459-3 - Human platelet lysate: from discard to value products in cell therapy and advanced cell-based medicine
• Grantee: Sheila Siqueira Andrade
• Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE
• FAPESP's process: 17/26317-1 - InGrowth, biomimetic product developed by platelet bioactivation platform: applications in the veterinary and research and development areas
• Grantee: Sheila Siqueira Andrade
• Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE