In vivo study of anti-inflammatory and antinociceptive activities of Copaifera pubiflora Benth oleoresin

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Simaro, Guilherme Venancio ; Lemos, Marivane ; da Silva, Jonas Joaquim Mangabeira ; Cunha, Wilson Roberto ; Carneiro, Luiza Junqueira ; Ambrosio, Sergio Ricardo ; Cunha, Nayanne Larissa ; de Andrade, Sergio Faloni ; Arruda, Caroline ; Bandero-Filho, Vilmar C. ; Sasse, Astrid ; Sheridan, Helen ; Bastos, Jairo Kenupp ; Andrade e Silva, Marcio Luis

• Document type: Journal article
• Source: NATURAL PRODUCT RESEARCH; v. 36, n. 4, p. 5-pg., 2020-11-24.

Abstract

Copaifera pubiflora Benth oleoresin (CPO) is used as an anti-inflammatory, wound healing, and antimicrobial. This paper reports the cytotoxic, anti-inflammatory, and antinociceptive activities of CPO. CPO (10 mg/kg) did not affect locomotor capacity in the open-field and rotarod tests and was not cytotoxic to CHO-k1, THP-1, and L929 cell lines. It was active in the formalin test at 3 mg/kg by 86 +/- 3% and 96 +/- 3%, respectively, for the first and second phases. At 10 mg/kg, CPO inhibited 90 +/- 7%, the pain in the mechanical hyperalgesia test. In the tail-flick test, CPO at 3 mg/kg affected the tail-flick latencies in mice by 77 +/- 20%, which in combination with naloxone was only partially reduced. At 3 mg/kg CPO inhibited 80 +/- 12% the carrageenan-induced paw edema, and at 3 mg/kg it reduced by 91 +/- 5% the nociception on acetic acid-induced abdominal writhing. Therefore, CPO possesses anti-inflammatory and antinociceptive activities. (AU)

• FAPESP's process: 11/13630-7 - Chemical and pharmacological validation of extracts and active compounds of Copaifera species
• Grantee: Jairo Kenupp Bastos
• Support Opportunities: Research Projects - Thematic Grants