Boosting life sciences research in Brazil: building a case for a local Drosophila stock center

Author(s)

Marcos T. Oliveira ^[1] ; Lucas Anhezini ^[2] ; Helena M. Araujo ; Marcus F. Oliveira ; Carlos A. Couto-Lima ^[5]

Affiliation

^[1] Universidade Estadual Paulista Júlio de Mesquita Filho. Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal. Departamento de Biotecnologia - Brasil

^[2] Universidade Federal de Alagoas. Instituto de Ciências Biológicas e da Saúde. Departamento de Histologia e Embriologia - Brasil

^[5] Universidade Estadual Paulista Júlio de Mesquita Filho. Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal. Departamento de Biotecnologia - Brasil

• Document type: Journal article
• Source: GENETICS AND MOLECULAR BIOLOGY; v. 47, n. 1 2024-02-19.

Abstract

Abstract Drosophila melanogaster is undoubtedly one of the most useful model organisms in biology. Initially used in solidifying the principles of heredity, and establishing the basic concepts of population genetics and of the synthetic theory of evolution, it can currently offer scientists much more: the possibility of investigating a plethora of cellular and biological mechanisms, from development and function of the immune system to animal neurogenesis, tumorigenesis and beyond. Extensive resources are available for the community of Drosophila researchers worldwide, including an ever-growing number of mutant, transgenic and genomically-edited lines currently carried by stock centers in North America, Europe and Asia. Here, we provide evidence for the importance of stock centers in sustaining the substantial increase in the output of Drosophila research worldwide in recent decades. We also discuss the challenges that Brazilian Drosophila scientists face to keep their research projects internationally competitive, and argue that difficulties in importing fly lines from international stock centers have significantly stalled the progression of all Drosophila research areas in the country. Establishing a local stock center might be the first step towards building a strong local Drosophila community that will likely contribute to all areas of life sciences research. (AU)

• FAPESP's process: 21/06711-2 - Modulation of tissue growth and biomass accumulation by the mitochondrial alternative oxidase
• Grantee: Marcos Túlio de Oliveira
• Support Opportunities: Research Grants - Young Investigators Grants - Phase 2
• FAPESP's process: 22/05632-4 - Genetic and metabolic interactions among lactate dehydrogenase, glycerol phosphate dehydrogenase and alternative oxidase
• Grantee: Carlos Antonio Couto Lima
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 14/02253-6 - Investigating the metabolic alterations caused by the transgenic expression of the mitochondrial alternative oxidase of Ciona intestinalis in Drosophila melanogaster
• Grantee: Marcos Túlio de Oliveira
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 17/04372-0 - Mitochondrial DNA: mechanisms for genome integrity maintenance and impact on disease
• Grantee: Nadja Cristhina de Souza Pinto
• Support Opportunities: Research Projects - Thematic Grants