Photochemical Synthesis and Ring-Opening of Aziridines and Epoxides: State-of-the-Art

Author(s)

Furniel, Lucas G. ; Correa, Arlene G.

• Document type: Journal article
• Source: CHEMPHOTOCHEM; v. 8, n. 9, p. 18-pg., 2024-06-15.

Abstract

The development of greener methods for the preparation of three-membered rings has increased in the last decade, not only due to their biological activity but also to the ring strain of those heterocycles that make them useful precursors of more complex molecules. In this work, the visible-light-promoted synthesis and ring-opening of aziridines and epoxides, reported in the last five years, were reviewed. Both homogeneous and heterogeneous catalysts were discussed and, in addition, the plausible mechanism pathways were highlighted. Aziridines and epoxides exhibit diverse biological activity and wide utility as precursors for more complex structures. Their combination with visible-light photocatalysis offers a versatile and greener synthetic tool. Therefore, the progress in photochemical and photocatalytic synthesis or ring-opening methods of these important strained heterocycles, reported in the last five years, is presented in this review. image (AU)

• FAPESP's process: 23/11454-4 - Photocatalytic synthesis of 1-pyrrolines under continuous flow conditions and synthesis of pyrrolo[2,1-a]isoquinolines for antiplasmodial evaluation
• Grantee: Lucas Giani Furniel
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 21/12394-0 - Sustainable synthetic methods employing catalysis, benign solvents, safer reagents, and bio-renewable feedstock
• Grantee: Arlene Gonçalves Corrêa
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
• Grantee: Glaucius Oliva
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC