| Full text | |
| Author(s): |
Fernandes-Junior, Wilson S.
;
Orzari, Luiz O.
;
Kalinke, Cristiane
;
Bonacin, Juliano A.
;
Janegitz, Bruno C.
Total Authors: 5
|
| Document type: | Journal article |
| Source: | Talanta; v. 275, p. 10-pg., 2024-05-03. |
| Abstract | |
Additive manufacturing is a technique that allows the construction of prototypes and has evolved a lot in the last 20 years, innovating industrial fabrication processes in several areas. In chemistry, additive manufacturing has been used in several functionalities, such as microfluidic analytical devices, energy storage devices, and electrochemical sensors. Theophylline and paracetamol are important pharmaceutical drugs where overdosing can cause adverse effects, such as tachycardia, seizures, and even renal failure. Therefore, this paper aims at the development of miniaturized electrochemical sensors using 3D printing and polylactic acid-based conductive carbon black commercial filament for theophylline and paracetamol detection. Electrochemical characterizations of the proposed sensor were performed to prove the functionality of the device. Morphological characterizations were carried out, in which chemical treatment could change the surface structure, causing the improvement of the analytical signal. Thus, the detection of theophylline at a linear range of 5.00 - 150 mu mol L -1 with a limit of detection of 1.2 mu mol L -1 was attained, and the detection of paracetamol at a linear range of 1.00 - 200 mu mol L -1 with a limit of detection of 0.370 mu mol L -1 was obtained, demonstrating the proposed sensor effectively detected pharmaceutical drugs. (AU) | |
| FAPESP's process: | 19/23342-0 - Development of novel immunosensor architechtures for the detection of Huntington and Parkinson Diseases biomarkers |
| Grantee: | Luiz Otávio Orzari |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 19/26953-0 - Electrochemical sensors and biosensors printed in 3D using graphene filament for detection of phenolic compounds |
| Grantee: | Wilson da Silva Fernandes Junior |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 17/21097-3 - Bee-agriculture interactions: perspectives to sustainable use |
| Grantee: | Osmar Malaspina |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |
| FAPESP's process: | 19/00473-2 - Development of 3-dimensional (3D) printed electrochemical biosensors with PLA polymer and graphene for the determination of biomolecules and diagnosis of diseases |
| Grantee: | Cristiane Kalinke |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |