Electrochemical sensors are gaining attention for providing faster analysis, higher sensibility and greater portability compared to other analytical techniques, such as chromatographic and spectroscopic techniques. Thus, by minimizing the cost of sensors, it was possible to use nanomaterials for their elaboration. With the emergence of 3-dimensional (3D) printing technology, carbon-based nanomaterials could combine with thermoplastic polymers, allowing the construction of electrochemical sensors and biosensors. Due to the attractiveness and the need to obtain even more sensitive and specific devices, the superficial modifications of these with nanomaterials, such as materials in the development of biosensors, gain space. In this regard, the development of biosensors is constantly growing due to their attractiveness and the possibility of using various biological materials in their modification, e.g. cells, enzymes, and others. The 3D printing technique allows the development of several prototypes with different structures, due to its relatively low cost of production and versatility. Among the various phenolic compounds evaluated in several scientific works, it is worth mentioning serotonin, which is greatly important in different fields, such as medical and pharmaceutical areas. Serotonin is a biomarker of several neurological and psychic disorders, such as Alzheimer's and depression. Likewise, catechol detection is also very important, as it is one of the main pollutants of watercourses due to its high aquatic solubility and high carcinogenicity. Therefore, as the conventional determination of analytes is too expensive, the purpose of this project is to develop electrochemical sensors using the 3D printing technique for serotonin detection and the modification of these devices to biosensors, in order to detect catechol, both in biological samples, with a more affordable approach.
News published in Agência FAPESP Newsletter about the scholarship: