New architectures of 3D printed sensors for detection of biomarkers and hydrogen peroxide

• Grant number: 21/03179-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: January 01, 2022
• Status: Discontinued
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Bruno Campos Janegitz
• Grantee: Vinicius Aparecido Oliani Pedro da Silva
• Host Institution: Centro de Ciências Agrárias (CCA). Universidade Federal de São Carlos (UFSCAR). Araras , SP, Brazil
• Associated research grant: 17/21097-3 - Bee-agriculture interactions: perspectives to sustainable use, AP.BTA.TEM
• Associated scholarship(s): 24/12885-1 - DEVELOPMENT OF NOVEL CONDUCTIVE FILAMENTS FOR 3D PRINTING ELECTROCHEMICAL SENSORS, BE.EP.DR

Abstract

Currently, technology has developed rapidly, and with it the need for faster and faster delivery of results. This need, in most cases, appears as demands at work, in relationships, and also self-demand. As a result of these demands, the body starts to feel the symptoms of stress, which when continuously stimulated can be chronic, causing damage to the immune and inflammatory system, causing a range of physical and psychological illnesses, which can lead to death. Thus, it is interesting to diagnose these damages early through biomarkers and subsequent monitoring of results for a better quality of life for patients. In this context, this doctoral project proposes the study of chemical substances generated with the stimulus of stress, which act as disease biomarkers and detection with specific electrochemical devices, as an option for rapid response analysis, sensitive, with low waste generation, and relatively low cost. This project consists of three proposals for sensors developed in 3D, namely: a printed sensor with a polymer-based conductive filament; a modified 3D printed sensor with thin-film biological material and hemoglobin for biosensing; and finally, an analysis system by hyphenated electrochemical and colorimetric techniques using paper fluidics. To obtain a better increase in the analytical signal, the surface treatment of the sensor printed with a conductive filament will also be studied. The study of voltammetric profiles of each architecture developed will also be carried out to promote improvements and seek information about the behavior and interactions of each system. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA SILVA, VINICIUS A. O. P.; STEFANO, JESSICA S.; KALINKE, CRISTIANE; BONACIN, JULIANO. A. A.; JANEGITZ, BRUNO. C. C.. Additive Manufacturing Sensor for Stress Biomarker Detection. CHEMOSENSORS, v. 11, n. 5, p. 14-pg., 2023-05-20. (22/06145-0, 19/00473-2, 17/21097-3, 21/03179-8, 21/07989-4)