Development of disposable devices with conductive inks and low cost substrates for the biosensing of hormonal dysfunctions and detection of Malaria

• Grant number: 19/23177-0
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Effective date (Start): March 01, 2020
• Effective date (End): July 31, 2024
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Bruno Campos Janegitz
• Grantee: Jéssica Rocha Camargo
• Host Institution: Centro de Ciências Agrárias (CCA). Universidade Federal de São Carlos (UFSCAR). Araras , SP, Brazil
• Associated research grant: 17/21097-3 - Bee-agriculture interactions: perspectives to sustainable use, AP.BTA.TEM
• Associated scholarship(s): 23/00321-3 - Screen-printed carbon electrodes for the detection of clinical and pharmaceutical compounds, BE.EP.DD

Abstract

Electrochemical devices that allow rapid analysis, miniaturized with high sensitivity are one of the most featured aspects in recent years. Conductive inks aligned to inert substrates allow the creation of these miniaturized electrochemical devices. In this project, we intend to make disposable sensory and biosensor architectures, with low cost materials. For the manufacture of conductive inks, a solvent-aligned polymer base in which it may be water or organic solvents and a conductive material, which may be carbonaceous or even metal materials such as silver and copper, will be used. The different inks made can also have their surface modified, resulting in an increase in electrochemical area and a reduction in the detection limits of these disposable devices. The modifications not only allow for an improvement over the sensing of such devices, but also with the aid of covalent bonding agents, can be a means for making biosensors. Many diseases need a quick and efficient diagnosis. Hormonal dysfunctions call our attention, since they are related to several diseases, among them one of the biggest causes of women death, the Breast Cancer. Malaria is another disease that is intended to be investigated, as a rapid and in situ immunosensing can decrease the mortality rates of this disease. Thus, it is desired to develop disposable and miniaturized systems that will be tested for neurotransmitter sensing and biosensing of Malaria and estrone, diseases that directly affect human health. (AU)

Scientific publications

(10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CAMARGO, JESSICA ROCHA; ORZARI, LUIZ OTAVIO; ARAUJO, DIELE APARECIDA GOUVEIA; DE OLIVEIRA, PAULO ROBERTO; KALINKE, CRISTIANE; ROCHA, DIEGO PESSOA; DOS SANTOS, ANDRE LUIZ; TAKEUCHI, REGINA MASSAKO; MUNOZ, RODRIGO ALEJANDRO ABARZA; BONACIN, JULIANO ALVES; et al. Development of conductive inks for electrochemical sensors and biosensors. Microchemical Journal, v. 164, MAY 2021. (17/21097-3, 19/23342-0, 13/22127-2, 19/23177-0, 19/00473-2, 17/23960-0, 19/01844-4)

HENRIQUE, JULIA MELO; CAMARGO, JESSICA ROCHA; DE OLIVEIRA, GEISER GABRIEL; STEFANO, JESSICA SANTOS; JANEGITZ, BRUNO CAMPOS. Disposable electrochemical sensor based on shellac and graphite for sulfamethoxazole detection. Microchemical Journal, v. 170, NOV 2021. (19/23177-0, 17/21097-3, 20/04189-4)

CAMARGO, JESSICA ROCHA; SILVA, TIAGO ALMEIDA; RIVAS, GUSTAVO A.; JANEGITZ, BRUNO C.. Novel eco-friendly water-based conductive ink for the preparation of disposable screen-printed electrodes for sensing and biosensing applications. Electrochimica Acta, v. 409, p. 9-pg., 2022-03-20. (17/21097-3, 19/23177-0)

BLASQUES, RODRIGO VIEIRA; DE OLIVEIRA, PAULO ROBERTO; KALINKE, CRISTIANE; BRAZACA, LAIS CANNIATTI; CRAPNELL, ROBERT D. D.; BONACIN, JULIANO ALVES; BANKS, CRAIG E. E.; JANEGITZ, BRUNO CAMPOS. Flexible Label-Free Platinum and Bio-PET-Based Immunosensor for the Detection of SARS-CoV-2. BIOSENSORS-BASEL, v. 13, n. 2, p. 19-pg., 2023-02-01. (19/00473-2, 17/21097-3, 18/19750-3, 19/23177-0, 21/07989-4, 13/22127-2)

BLASQUES, RODRIGO VIEIRA; STEFANO, JESSICA S.; CAMARGO, JESSICA R.; SLIVA, LUIZ R. GUTERRES E.; BRAZACA, LAIS CANNIATTI; JANEGITZ, BRUNO CAMPOS. Disposable Prussian blue-anchored electrochemical sensor for enzymatic and non-enzymatic multi-analyte detection. SENSORS AND ACTUATORS REPORTS, v. 4, p. 11-pg., 2022-09-01. (18/19750-3, 17/21097-3, 19/23177-0)

GUSTANI, FLAVIA MARIA; SILVA, TIAGO ALMEIDA; CAMARGO, JESSICA ROCHA; DE SOUZA CARVALHO, JEFFERSON HENRIQUE; JANEGITZ, BRUNO CAMPOS; FUJIHARA, RICARDO TOSHIO. Synthesis, Attractiveness and Effectiveness of Chitosan-Tapioca Encapsulates in Atta Sexdens (Hymenoptera: Formicidae). JOURNAL OF POLYMERS AND THE ENVIRONMENT, FEB 2021. (17/21097-3, 19/23177-0)

GUSTANI, FLAVIA MARIA; SILVA, TIAGO ALMEIDA; CAMARGO, JESSICA ROCHA; DE SOUZA CARVALHO, JEFFERSON HENRIQUE; JANEGITZ, BRUNO CAMPOS; FUJIHARA, RICARDO TOSHIO. Synthesis, Attractiveness and Effectiveness of Chitosan-Tapioca Encapsulates in Atta Sexdens (Hymenoptera: Formicidae). JOURNAL OF POLYMERS AND THE ENVIRONMENT, v. 29, n. 9, p. 2869-2880, SEP 2021. (17/21097-3, 19/23177-0)

DE OLIVEIRA, GABRIELA CAROLINA MAURUTO; CAMARGO, JESSICA ROCHA; VIEIRA, NIRTON CRISTI SILVA; JANEGITZ, BRUNO CAMPOS. A new disposable electrochemical sensor on medical adhesive tape. Journal of Solid State Electrochemistry, v. 24, n. 10, JUN 2020. (17/21898-6, 17/21097-3, 17/17572-8, 19/23177-0)

SILVA, RAFAEL MATIAS; DA SILVA, ALEXSANDRA DIAS; CAMARGO, JESSICA ROCHA; DE CASTRO, BRUNA SANTOS; MEIRELES, LAIS MUNIZ; SILVA, PATRICIA SOARES; JANEGITZ, BRUNO CAMPOS; SILVA, TIAGO ALMEIDA. Carbon Nanomaterials-Based Screen-Printed Electrodes for Sensing Applications. BIOSENSORS-BASEL, v. 13, n. 4, p. 38-pg., 2023-04-01. (17/21097-3, 19/23177-0, 23/00321-3)

CAMARGO, JESSICA R.; FERNANDES-JUNIOR, WILSON S.; AZZI, DEBORAH C.; ROCHA, RAQUEL G.; FARIA, LUCAS, V; RICHTER, EDUARDO M.; MUNOZ, RODRIGO A. A.; JANEGITZ, BRUNO C.. Development of New Simple Compositions of Silver Inks for the Preparation of Pseudo-Reference Electrodes. BIOSENSORS-BASEL, v. 12, n. 9, p. 17-pg., 2022-09-01. (20/04189-4, 19/23177-0, 17/21097-3, 19/26953-0)