Nowadays, Huntington's and Parkinson's Diseases are two of the main neurodegenerative diseases that plague mankind. Having their first symptoms after adulthood, they lead to a devastating degradation of the motor and nervous systems, incurable. Thus, early diagnosis and control are essential for a better quality of life of patients, so that the study of biomarkers for both is considerably growing. In search of a relatively low cost alternative, low waste generation and fast response, this project proposes the construction of new electrochemical devices for the biosensing of these biomarkers. Both proposals aim the formation of labelfree immunosensors with polyclonal antibodies, which will be produced from two research fronts: the first being of carbon-conductive inks; and the second, with three-dimensional printing of electrode systems using carbon conductive filaments. With metallic nanoparticles, it will be possible to modify both the surface of the electrodes or directly in the formulation of these materials, pursuing a greater interaction between device and antibody/antigen molecules. In addition, during the application of these architectures, studies about the electrochemical profiles with various probes of different properties will be carried out, seeking a better clarification of each system interactions. (AU)
News published in Agência FAPESP Newsletter about the scholarship:
CAMARGO, JESSICA ROCHA;
ORZARI, LUIZ OTAVIO;
ARAUJO, DIELE APARECIDA GOUVEIA;
DE OLIVEIRA, PAULO ROBERTO;
ROCHA, DIEGO PESSOA;
DOS SANTOS, ANDRE LUIZ;
TAKEUCHI, REGINA MASSAKO;
MUNOZ, RODRIGO ALEJANDRO ABARZA;
BONACIN, JULIANO ALVES;
JANEGITZ, BRUNO CAMPOS.
Development of conductive inks for electrochemical sensors and biosensors.
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