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Development of novel immunosensor architechtures for the deterction of Huntington and Parkinson Diseases biomarkers

Grant number: 19/23342-0
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): March 01, 2020
Effective date (End): February 29, 2024
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal researcher:Bruno Campos Janegitz
Grantee:Luiz Otávio Orzari
Home Institution: Centro de Ciências Agrárias (CCA). Universidade Federal de São Carlos (UFSCAR). Araras , SP, Brazil
Associated research grant:17/21097-3 - Bee-agriculture interactions: perspectives to sustainable use, AP.TEM

Abstract

Nowadays, Huntington's and Parkinson's Diseases are two of the main neurodegenerative diseases that plague mankind. Having their first symptoms after adulthood, they lead to a devastating degradation of the motor and nervous systems, incurable. Thus, early diagnosis and control are essential for a better quality of life of patients, so that the study of biomarkers for both is considerably growing. In search of a relatively low cost alternative, low waste generation and fast response, this project proposes the construction of new electrochemical devices for the biosensing of these biomarkers. Both proposals aim the formation of labelfree immunosensors with polyclonal antibodies, which will be produced from two research fronts: the first being of carbon-conductive inks; and the second, with three-dimensional printing of electrode systems using carbon conductive filaments. With metallic nanoparticles, it will be possible to modify both the surface of the electrodes or directly in the formulation of these materials, pursuing a greater interaction between device and antibody/antigen molecules. In addition, during the application of these architectures, studies about the electrochemical profiles with various probes of different properties will be carried out, seeking a better clarification of each system interactions. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FREITAS, RAFAELA C.; ORZARI, LUIZ O.; FERREIRA, LUIS M. C.; PAIXAO, THIAGO R. L. C.; COLTRO, WENDELL K. T.; VICENTINI, FERNANDO C.; JANEGITZ, BRUNO C. Electrochemical determination of melatonin using disposable self-adhesive inked paper electrode. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, v. 897, SEP 15 2021. Web of Science Citations: 0.
CAMARGO, JESSICA ROCHA; ORZARI, LUIZ OTAVIO; ARAUJO, DIELE APARECIDA GOUVEIA; DE OLIVEIRA, PAULO ROBERTO; KALINKE, CRISTIANE; ROCHA, DIEGO PESSOA; DOS SANTOS, ANDRE LUIZ; TAKEUCHI, REGINA MASSAKO; MUNOZ, RODRIGO ALEJANDRO ABARZA; BONACIN, JULIANO ALVES; JANEGITZ, BRUNO CAMPOS. Development of conductive inks for electrochemical sensors and biosensors. Microchemical Journal, v. 164, MAY 2021. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.