| Full text | |
| Author(s): |
Moraes, Fernanda dos Santos Rapucci
;
Moraes, Luis Henrique Rapucci
;
Macedo, Aline Barbosa
;
Valduga, Amanda Harduim
;
Mizobuti, Daniela Sayuri
;
da Rocha, Guilherme Luiz
;
da Silva, Heloina Nathallie Mariano
;
Salvador, Marcos Jose
;
Minatel, Elaine
Total Authors: 9
|
| Document type: | Journal article |
| Source: | Journal of Essential Oil Bearing Plants; v. 27, n. 1, p. 13-pg., 2024-01-06. |
| Abstract | |
The commercial essential oil obtained from the steam distillation of cold-pressed oil from Citrus aurantifolia (Christm.) Swingle fruits (OCA), after chemical characterization by gas chromatography-mass spectrometry (GC-MS), was investigated for antioxidant and anti-inflammatory activities and related signaling pathways in dystrophic muscle cells. The chemical composition of OCA showed 24 compounds with a predominance of monoterpenes, such as limonene (42.6%), cymene (11.8%), alpha-terpineol (11.8%), terpinolene (5.3%) and gamma-terpinene (4.6%). DPHH and ORAC assays showed a significant antioxidant activity of OCA. Because the OCA is rich in limonene, it exhibited marked anti-inflammatory (as indicated by the reduction of TNF- alpha and NF-kappa B levels) and antioxidant effects (as indicated by the reduction of 4-HNE-protein adducts, SOD-2, GSR and H2O2 levels) on dystrophic muscle cells. These effects appear to be mediated through the activation of PGC-1 alpha pathway. Therefore, OCA can be considered a promising bioactive for therapeutic applications in dystrophinopathies. (AU) | |
| FAPESP's process: | 12/09101-1 - Investigation of treatment with 24-epibrassinolide in plant development, profile of volatile constituents and biological activities of essential oils from Cymbopogon citratus, Cymbopogon flexuosus and Mentha pulegium |
| Grantee: | Marcos José Salvador |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 21/09693-5 - Use of microbiome technologies and bioassays for the search for new bioactive compounds in plants and symbionts: implications for metabolic responses, molecular diversity and bioactivity |
| Grantee: | Marcos José Salvador |
| Support Opportunities: | BIOTA-FAPESP Program - Regular Research Grants |
| FAPESP's process: | 17/01638-0 - TEMPOL: POTENTIAL ANTIOXIDANT THERAPY FOR DYSTROPHIC MUSCULAR FIBERS |
| Grantee: | Elaine Minatel |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 10/01087-4 - In vivo and in vitro treatment, with N-acetylcistein and Deferoxamin in dystrophic mouse |
| Grantee: | Luis Henrique Rapucci Moraes |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 13/17732-4 - In vivo and in vitro effect of the antiinflammatory and antioxidant on dystrophic muscle fibers of Mdx mice |
| Grantee: | Elaine Minatel |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 06/06079-4 - Search of antioxidants and antimicrobials in Gomphreneae tribe species |
| Grantee: | Marcos José Salvador |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/03726-8 - Integrated chemical and biological study in the search for bioactive substances in plants* and development of analytical procedures. *(Amaranthaceae, Gesneriaceae, Myrtaceae e Annonaceae) |
| Grantee: | Marcos José Salvador |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 11/02474-4 - Treatment in vivo and in vitro with calcium blocker and antioxidant in mdx mice |
| Grantee: | Elaine Minatel |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 20/09733-4 - Effect of photobiomodulation and antioxidant therapies on cellular, tissue, molecular and biochemical events on dystrophic muscle fibers in Mdx mice |
| Grantee: | Elaine Minatel |
| Support Opportunities: | Regular Research Grants |