Pesticide-Induced Inflammation at a Glance

Author(s)

Lopes-Ferreira, Monica ; Farinha, Luiz Rogerio Ludwig ; Costa, Yasmin Stefanie Oliveira ; Pinto, Felipe Justiniano ; Disner, Geonildo Rodrigo ; da Rosa, Joao Gabriel dos Santos ; Lima, Carla

• Document type: Journal article
• Source: TOXICS; v. 11, n. 11, p. 15-pg., 2023-11-01.

Abstract

The increasing number of studies reporting the risks of the exposure to pesticides aligned with the intensified use of such hazardous chemicals has emerged as a pressing contemporary issue, notably due to the potential effects to both the environment and human health. Pesticides, while broadly applied in modern agriculture for pest control and crop protection, have raised concerns due to their unintended effects on non-target organisms. The immune system exerts a key role in the protection against the exposome, which could result in cellular imbalances and tissue damage through the inflammatory response. Pesticides, which encompass a diverse array of chemicals, have been linked to inflammation in experimental models. Therefore, the aim of this review is to discuss the increasing concern over the risks of pesticide exposure focusing on the effects of various chemical classes on inflammation by covering, as broadly as possible, different experimental approaches as well as the multiple or co-exposure of pesticides. Overall, pesticides potentially induce inflammation in different experimental models, manifested through skin irritation, respiratory impairment, or systemic effects. The connection between pesticides and inflammation highlights the importance of proper handling and regulation of these substances and underscores the need for research into safer and sustainable practices to reduce our reliance on synthetic pesticides and fertilizers. (AU)

• FAPESP's process: 13/07467-1 - CeTICS - Center of Toxins, Immune-Response and Cell Signaling
• Grantee: Hugo Aguirre Armelin
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 21/08891-8 - Assessment of the pharmacological mechanisms of the peptide TnP isolated from Thalassophryne nattereri venom in the therapy of Hypoxic Retinopathy in Zebrafish
• Grantee: João Gabriel dos Santos da Rosa
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 21/06084-8 - Evaluation of the functional importance of Natterin family proteins in the activation of the inflammasome in zebrafish
• Grantee: Carla Lima da Silva
• Support Opportunities: Regular Research Grants
• FAPESP's process: 19/27677-7 - Study of the induction of regulatory microRNAs by TNP dependent on Aryl hydrocarbon Receptor (AhR) activation
• Grantee: Geonildo Rodrigo Disner
• Support Opportunities: Scholarships in Brazil - Post-Doctoral