| Full text | |
| Author(s): |
de Almeida, Herllan V.
;
Bomediano, Mateus P.
;
Catori, Daniele M.
;
Silva, Elizaura H. C.
;
de Oliveira, Marcelo G.
Total Authors: 5
|
| Document type: | Journal article |
| Source: | BIOMATERIALS SCIENCE; v. 13, n. 4, p. 17-pg., 2025-01-07. |
| Abstract | |
The pivotal roles played by nitric oxide (NO) in tissue repair, inflammation, and immune response have spurred the development of a wide range of NO-releasing biomaterials. More recently, 3D printing techniques have significantly broadened the potential applications of polymeric biomaterials in biomedicine. In this context, the development of NO-releasing biomaterials that can be fabricated through 3D printing techniques has emerged as a promising strategy for harnessing the benefits of localized NO release from implantable devices, tissue regeneration scaffolds, or bandages for topical applications. Although 3D printing techniques allow for the creation of polymeric constructs with versatile designs and high geometric precision, integrating NO-releasing functional groups or molecules into these constructs poses several challenges. NO donors, such as S-nitrosothiols (RSNOs) or diazeniumdiolates (NONOates), may release NO thermally, complicating their incorporation into resins that require heating for extrusion-based 3D printing. Conversely, NO released photochemically from RSNOs effectively inhibits radical propagation, thus hindering photoinduced 3D printing processes. This review outlines the primary strategies employed to overcome these challenges in developing NO-releasing biomaterials via 3D printing, and explores future prospects in this rapidly evolving field. (AU) | |
| FAPESP's process: | 16/02414-5 - Topical and absorbable biomaterials for the local nitric oxide release |
| Grantee: | Marcelo Ganzarolli de Oliveira |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 22/14645-2 - Nitric oxide releasing hydrogels and vascular prosthesis for cardiovascular applications |
| Grantee: | Marcelo Ganzarolli de Oliveira |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 22/13352-1 - Vascular prosthesis of nitric oxide donor micellar hydrogels |
| Grantee: | Mateus Peres Bomediano |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |