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Acute toxicity and sublethal effects of thiamethoxam on the stingless bee Scaptotrigona postica: Survival, neural morphology, and enzymatic responses

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Author(s):
Maloni, Geovana ; Miotelo, Lucas ; Otero, Igor Vinicius Ramos ; de Souza, Fernanda Carolaine ; Nocelli, Roberta Cornelio Ferreira ; Malaspina, Osmar
Total Authors: 6
Document type: Journal article
Source: Environmental Pollution; v. 369, p. 10-pg., 2025-03-15.
Abstract

Native and cultivated plants in the Neotropics benefit from the pollination services provided by stingless bees. The use of neonicotinoid insecticides negatively impacts bee health, even though bees are not their primary targets. This study determined the oral mean lethal concentration (LC50) of thiamethoxam (TMX) after 24 h of exposure for the stingless bee Scaptotrigona postica. Based on the LC50 value (0.11 ng a.i./mu L) obtained, two fractions of this value (1/10 and 1/100 LC50) were selected to assess survival time (LT50), as well as to conduct neural morphological and enzymatic analyses. The LC50/100 group had a LT50 of 15 days, compared to 17 days in the control group, while the LC50/10 group survived for 8 days. Morphological analyses revealed increased Kenyon cell spacing and pyknosis in the mushroom bodies after 1, 3, and 6 days of exposure, suggesting that thiamethoxam adversely affects the brain of S. postica. Regarding enzymatic activity, comparisons between the control and the two sublethal concentrations revealed that Carboxylesterase and Glutathione S-transferase (GST) activity increased in the abdomens after six days of exposure. GST activity also increased in the bees' heads for the LC50/10 concentration after six days of exposure (Control x TMX group). The enzymatic results suggests that thiamethoxam induces oxidative stress in S. postica. The results presented underscore the necessity of considering stingless bees in regulatory decisions regarding the use of insecticides, ensuring that the risks to this important group of pollinators are adequately assessed. (AU)

FAPESP's process: 17/21097-3 - Bee-agriculture interactions: perspectives to sustainable use
Grantee:Osmar Malaspina
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 20/03527-3 - Differential gene expression of Melipona scutellaris Malpighi tubule transcriptomes exposed to thiamethoxam
Grantee:Lucas Miotelo
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 21/01359-9 - Effects of the insecticide thiamethoxam on Scaptotrigona postica Latreille, 1807 (Hymenoptera, Meliponina): determination of the average lethal concentration and analysis of enzyme activity
Grantee:Geovana Maloni da Silva
Support Opportunities: Scholarships in Brazil - Scientific Initiation