The Hygienic Significance of Microbiota and Probiotics for Human Wellbeing

Author(s)

Todorov, Svetoslav D. ; Tagg, John ; Algburi, Ammar ; Tiwari, Santosh Kumar ; Popov, Igor ; Weeks, Richard ; Mitrokhin, Oleg V. ; Kudryashov, Ilya A. ; Kraskevich, Denis A. ; Chikindas, Michael L.

• Document type: Journal article
• Source: PROBIOTICS AND ANTIMICROBIAL PROTEINS; v. N/A, p. 31-pg., 2024-12-17.

Abstract

The human body can be viewed as a combination of ecological niches inhabited by trillions of bacteria, viruses, fungi, and parasites, all united by the microbiota concept. Human health largely depends on the nature of these relationships and how they are built and maintained. However, personal hygiene practices have historically been focused on the wholesale elimination of pathogens and "hygiene-challenging microorganisms" without considering the collateral damage to beneficial and commensal species. The microbiota can vary significantly in terms of the qualitative and quantitative composition both between different people and within one person during life, and the influence of various environmental factors, including age, nutrition, bad habits, genetic factors, physical activity, medication, and hygienic practices, facilitates these changes. Disturbance of the microbiota is a predisposing factor for the development of diseases and also greatly influences the course and severity of potential complications. Therefore, studying the composition of the microbiota of the different body systems and its appropriate correction is an urgent problem in the modern world. The application of personal hygiene products or probiotics must not compromise health through disruption of the healthy microbiota. Where changes in the composition or metabolic functions of the microbiome may occur, they must be carefully evaluated to ensure that essential biological functions are unaffected. As such, the purpose of this review is to consider the microbiota of each of the "ecological niches" of the human body and highlight the importance of the microbiota in maintaining a healthy body as well as the possibility of its modulation through the use of probiotics for the prevention and treatment of certain human diseases. (AU)

• FAPESP's process: 23/05394-9 - Multitasking of bacteriocinogenic beneficial microorganisms (lactic acid bacteria and Bacillus spp.) in food safety and health promoting applications
• Grantee: Svetoslav Dimitrov Todorov
• Support Opportunities: Regular Research Grants