Evaluation of antimicrobial activity and biocompatibility of a medicament paste co...
| Full text | |
| Author(s): |
Gomes Martins, Carlos Henrique
[1]
;
Carvalho, Tatiane Cruz
[1]
;
Mendes Souza, Maria Gorete
[1]
;
Ravagnani, Christian
[2]
;
Peitl, Oscar
[2]
;
Zanotto, Edgar Dutra
[2]
;
Panzeri, Heitor
[3]
;
Casemiro, Luciana Assirati
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Franca, Lab Res Appl Microbiol, BR-14404600 Franca, SP - Brazil
[2] Univ Fed Sao Carlos, Dept Mat Engn, Vitreous Mat Lab, BR-13565905 Sao Carlos, SP - Brazil
[3] Univ Sao Paulo, Dept Dent Mat & Prosthodont, Fac Dent Ribeirao Preto, BR-14040904 Ribeirao Preto, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE; v. 22, n. 6, p. 1439-1446, JUN 2011. |
| Web of Science Citations: | 22 |
| Abstract | |
This study assessed the antimicrobial activity of a new bioactive glass-ceramic (Biosilicate (R)) against anaerobic, microaerophilic, and facultative anaerobic microorganisms. Evaluation of the antimicrobial activity was carried out by three methods, namely agar diffusion, direct contact, and minimal inhibitory concentration (MIC). For the agar diffusion technique, bio glass-ceramic activity was observed against various microorganisms, with inhibition haloes ranging from 9.0 +/- 1.0 to 22.3 +/- 2.1 mm. For the direct contact technique, Biosilicate (R) displayed activity against all the microorganisms, except for S. aureus. In the first 10 min of contact between the microorganisms and Biosilicate (R), there was a drastic reduction in the number of viable cells. Confirming the latter results, MIC showed that the Biosilicate (R) inhibited the growth of microorganisms, with variations between <= 2.5 and 20 mg/ml. The lowest MIC values (7.5 to <= 2.5 mg/ml) were obtained for oral microorganisms. In conclusion, Biosilicate (R) exhibits a wide spectrum of antimicrobial properties, including anaerobic bacteria. (AU) | |
| FAPESP's process: | 07/08179-9 - Kinetic processes in glasses and glass ceramics |
| Grantee: | Edgar Dutra Zanotto |
| Support type: | Research Projects - Thematic Grants |