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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Direct injection of native aqueous matrices by achiral-chiral chromatography ion trap mass spectrometry for simultaneous quantification of pantoprazole and lansoprazole enantiomers fractions

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Author(s):
Barreiro, Juliana Cristina [1] ; Vanzolini, Kenia Lourenco [1] ; Cass, Quezia Bezerra [1]
Total Authors: 3
Affiliation:
[1] Univ Fed Sao Carlos, Dept Chem, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of Chromatography A; v. 1218, n. 20, p. 2865-2870, MAY 20 2011.
Web of Science Citations: 38
Abstract

A two-dimensional liquid chromatography system coupled to ion-trap tandem mass spectrometer (2DLC-IT-MS/MS) was employed for the simultaneous quantification of pantoprazole and lansoprazole enantiomers fractions. A restricted access media of bovine serum albumin octyl column (RAM-BSA C(8)) was used in the first dimension for the exclusion of the humic substances, while a polysaccharide-based chiral column was used in the second dimension for the enantioseparation of both pharmaceuticals. The results described here show good selectivity, extraction efficiency, accuracy, and precision with detection limits of 0.200 and 0.150 mu g L(-1) for the enatiomers of pantoprazole and lansoprazole respectively, while employing a small amount (1.0 mL) of native water sample per injection. This work reports an innovative assay for monitoring work, studies of biotic and abiotic enantioselective degradation and temporal changes of enantiomeric fractions. (C) 2011 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 06/05126-9 - Enantiomeric determination of pharmaceutical drugs: omeprazole, lansoprazole and pantoprazole in urban wastewater in the city of São Carlos, SP
Grantee:Kenia Lourenço Vanzolini
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 08/05778-1 - Chiral pharmaceuticals in wastewaters: quantification and studies of enantioselective separation mechanisms
Grantee:Juliana Cristina Barreiro
Support Opportunities: Scholarships in Brazil - Post-Doctoral