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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Role of Enamel Matrix Derivative Protein in Minimally Invasive Surgery in Treating Intrabony Defects in Single-Rooted Teeth: A Randomized Clinical Trial

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Author(s):
Ribeiro, Fernanda V. [1] ; Casarin, Renato C. V. [1] ; Junior, Francisco H. N. [1] ; Sallum, Enilson A. [1] ; Casati, Marcio Z. [1]
Total Authors: 5
Affiliation:
[1] Univ Estadual Campinas, Dept Prosthodont & Periodont, Sch Dent Piracicaba, BR-13414903 Piracicaba, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of Periodontology; v. 82, n. 4, p. 522-532, APR 2011.
Web of Science Citations: 21
Abstract

Background: This study investigates the impact of enamel matrix derivative (EMD) proteins on the outcome of a minimally invasive surgical technique (MIST) for the treatment of intrabony defects. Methods: Thirty patients who presented with intrabony defects were randomly assigned to treatment with: 1) MIST plus EMD or 2) MIST alone. Probing depth (PD), position of the gingival margin (PGM), and relative clinical attachment level (RCAL) were evaluated at 3 and 6 months after treatment. Radiographs and markers in gingival crevicular fluid associated with periodontal regeneration were also evaluated. Results: Significant PD reductions, RCAL gains, and no changes in PGM were obtained at 3 and 6 months in both groups. Clinical and radiographic evaluations and levels of mediators of wound healing did not present differences between therapies at any time. Conclusion: The use of EMD did not provide superior benefits on the outcome of the minimally invasive surgical approach for the treatment of intrabony defects. J Periodontol 2011;82:522-532. (AU)