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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Imbalance of Tumor Suppression Genes Expression Following Rat Tongue Carcinogenesis Induced by 4-Nitroquinoline 1-Oxide

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Author(s):
Ribeiro, Daniel Araki [1, 2] ; Cuzzuol Fracalossi, Ana Carolina [1] ; Uatari, Silvia Akemi [2] ; Fujiyama Oshima, Celina Tizuko [1] ; Favero Salvadori, Daisy Maria [3]
Total Authors: 5
Affiliation:
[1] Univ Fed Sao Paulo, UNIFESP, Dept Pathol, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, UNIFESP, Dept Biosci, Sao Paulo, SP - Brazil
[3] Sao Paulo State Univ, UNESP, Dept Pathol, Botucatu Med Sch, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: IN VIVO; v. 23, n. 6, p. 937-942, NOV-DEC 2009.
Web of Science Citations: 4
Abstract

This study was undertaken to investigate, by immunohistochemistry, the expression of some tumor suppressor genes such asp 16, p21 and Retinoblastoma (Rb) during 4-Nitroquinoline I-oxide induced rat tongue carcinogenesis. Male Wistar rats were distributed into three groups of 10 animals each and treated with 50 ppm 4NQO solution through their drinking water for 4, 12 or 20 weeks. Ten animals were used as negative control. Neither histopathological abnormalities were induced in the epithelium after 4 weeks of carcinogen exposure, not-statistically significant differences (p>0.05) in expression of all the tumor suppressor genes were found when compared to the negative control. However, the levels of Rb were increased (p<0.05) in pre-neoplastic lesions at 12 weeks following carcinogen exposure. In well-differentiated squamous cell carcinoma induced after 20 weeks of treatment with 4NQO, p16 and Rb were expressed in some tumor cells. Taken together, the results support the belief that the expression of Rb is closely event-related to malignant transformation and conversion of the oral mucosa, being a reliable biomarker linked to oral cancer pathogenesis. (AU)

FAPESP's process: 07/01228-4 - Medium-term oral carcinogenesis assay induced by 4-nitroquinoline 1-oxide in rats: putative biomarkers involved into its pathogenesis
Grantee:Daniel Araki Ribeiro
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 07/08210-3 - Medium-term oral carcinogenesis assay induced by 4-nitroquinoline 1-oxide in rats: putative biomarkers involved into its pathogenesis
Grantee:Ana Carolina Cuzzuol Fracalossi
Support Opportunities: Scholarships in Brazil - Doctorate