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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Study of the electrochemical reduction of amoebicide teclozan and its amperometric determination in pharmaceutical formulations

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Author(s):
Santos, Andri L. [1] ; Takeuchi, Regina M. [2] ; Stradiotto, Nelson R. [2] ; Esteves, Ana Paula [3] ; Medeiros, Maria Jose [3]
Total Authors: 5
Affiliation:
[1] Univ Fed Uberlandia, Fac Ciencias Integradas Pontal, BR-38302000 Ituiutaba, MG - Brazil
[2] Univ Estadual Paulista, BR-14801970 Araraquara, SP - Brazil
[3] Univ Minho, Ctr Quim, P-4704553 Braga - Portugal
Total Affiliations: 3
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 19, n. 6, p. 1144-1152, 2008.
Web of Science Citations: 2
Abstract

The electrochemical reduction of amoebicide Teclozan (TEC) was studied on a glassy carbon electrode in acetonitrile. Controlled-potential electrolyses were performed for coulometric and preparative purposes. The electrogenerated products were isolated by liquid-liquid extraction and characterized by ¹H NMR. It was observed that TEC presents two voltammetric peaks, each one associated with the cleavage of two C-Cl bonds. In presence of a proton donor it was observed that the first peak at -1.8 V promotes mainly the reduction of the groups CHCl2 to CH2Cl and the second one at -2.2 V promotes the reduction of the groups CH2Cl to CH3 giving as the sole product the completely dechlorinated TEC derivative with yields between 82 and 97%. In addition, a comparative study between the analytical performance of voltammetric techniques and amperometric detection of TEC in hydrodynamic conditions was performed. The amperometric detection was more sensitive than all evaluated voltammetric techniques, providing a detection limit of 8.9 × 10-6 mol L-1. (AU)