Oxidized low-density lipoproteins and their antibodies: Relationships with the reverse cholesterol transport and carotid atherosclerosis in adults without cardiovascular diseases

Author(s):Show less -

Ferreira, Paolla F. C. ^{[1, 2]} ; Zago, Vanessa H. S. ^{[1, 2]} ; D'Alexandri, Fabio L. ^{[1, 2]} ; Panzoldo, Natalia B. ^{[1, 2]} ; Gidlund, Magnus A. ^[3] ; Nakamura, Rui T. ^[4] ; Schreiber, Roberto ^{[1, 2]} ; Parra, Eliane S. ^{[1, 2]} ; Santiago, Fernanda D. ^{[1, 2]} ; Nakandakare, Edna R. ^[5] ; Quintao, Eder C. R. ^[5] ; de Faria, Eliana C. ^{[1, 2]}

Affiliation

^[1] Univ Campinas UNICAMP, Dept Clin Pathol, Sch Med Sci, Sao Paulo - Brazil

^[2] Univ Campinas UNICAMP, Ctr Med & Expt Surg NMCE, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Inst Biol Sci, Lab Immunophysiopathol, Sao Paulo - Brazil

^[4] Diagnost Image Lab, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Fac Med Sci, Lipids Lab, Sao Paulo - Brazil

• Document type: Journal article
• Source: Clinica Chimica Acta; v. 413, n. 19-20, p. 1472-1478, OCT 9 2012.
• Web of Science Citations: 3

Abstract

Background: Metabolic predictors and the atherogenicity of oxidized LDL (oxLDL) and the specific antibodies against oxLDL (oxLDL Ab) are unclear and controversial. Methods: In 107 adults without atherosclerotic manifestations, we measured oxLDL and oxLDL Ab, and also the activities of CETP. PLTP, lipases and the carotid intima-media thickness (cIMT). Comparisons were performed for the studied parameters between the lowest and the highest tertile of oxLDL and oxLDL Ab, and the relationships between studied variables were evaluated. Results: Subjects with higher oxLDL Ab present reduced hepatic lipase activity and borderline increased cIMT. In the highest oxLDL tertile, besides the higher levels of total cholesterol, LDL-C and apoB100, we found reduced CETP activity and higher cIMT. A significant correlation between oxLDL Ab and cIMT, independent of oxLDL, and a borderline correlation between oxLDL and cIMT independent of oxLDL Ab were found. In the multivariate analysis, apoAl was a significant predictor of oxLDL Ab, in contrast to regulation of oxLDL by apoB100, PLTP and inverse of CETP. Conclusions: In adults without atherosclerotic disease, the metabolic regulation and carotid atherosclerosis of oxLDLAb and oxLDL groups, characterized a dual trait in oxLDL Ab, as a contributor to carotid atherosclerosis, much less so than oxidized LDL, and with a modest atheroprotective role. (C) 2012 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 06/60585-9 - Relation of the plasma HDL-cholesterol concentration with blood monocyte and whole body cholesterol metabolism parameters
• Grantee: Eder Carlos Rocha Quintão
• Support Opportunities: Research Projects - Thematic Grants