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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Impact of myocardial infarction on cardiac autonomic function in diabetic rats

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Author(s):
Rodrigues, Bruno [1, 2] ; Mostarda, Cristiano T. [2] ; Jorge, Luciana [2] ; Barboza, Catarina A. [1] ; Grans, Camilla F. [1] ; De Angelis, Katia [3] ; Irigoyen, Maria Claudia [2]
Total Authors: 7
Affiliation:
[1] Univ Sao Judas Tadeu, Human Movement Lab, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Hypertens Unit, Heart Inst InCor, Sao Paulo - Brazil
[3] Nove Julho Univ, Translat Physiol Lab, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF DIABETES AND ITS COMPLICATIONS; v. 27, n. 1, p. 16-22, JAN-FEB 2013.
Web of Science Citations: 8
Abstract

Aims: We evaluated autonomic and hemodynamic parameters and maximal oxygen consumption (VO(2)max) as possible determinants of mortality in streptozotocin (STZ) diabetic rats after myocardial infarction (MI). Method: Male Wistar rats were divided into (n=8 of each): control sham (CS), diabetes sham (DS), MI (I), and diabetes +MI (DI). MI was induced 15 days after STZ induction. VO(2)max was measured at 3 (basal), 30, 60, and 91 days after MI. Hemodynamic and autonomic parameters were evaluated 92 days after MI. Results: MI area was similar in infarcted groups (similar to 44%). Mortality rate increased in the DI (70%) compared with I (53%) group. Cardiopulmonary baroreflex, sympathetic (48%) and vagal (33%) tonus, low frequency (LF) band (57%), and LF/high frequency (HF) band ratio (53%) were reduced in DI compared with I animals. Furthermore, cardiac output (CO), peripheral vascular resistance (PVR) impairment, and VO(2)max reductions were observed in the DI compared with the I group. Conclusions: Our data suggest that the CO and PVR changes as well as VO(2)max reduction were probably associated with additional cardiac autonomic control impairment, and, consequently, increased mortality rate in diabetic rats after a chronic myocardial infarction. (C) 2013 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 07/58942-0 - From the bench to clinical trials: development of biomarkers as response predictors to therapy and target organs damage in systemic arterial hypertension
Grantee:Eduardo Moacyr Krieger
Support Opportunities: Research Projects - Thematic Grants