New Screen Printed Electrode Based on Graphite and Polyurethane Composite for the Determination of Acetaminophen

Author(s)

Saciloto, Thalita Rocha ^[1] ; Cervini, Priscila ^[1] ; Gomes Cavalheiro, Eder Tadeu ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Quim Sao Carlos, Dept Quim & Fis Mol, BR-13560970 Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: Analytical Letters; v. 46, n. 2, p. 312-322, 2013.
• Web of Science Citations: 9

Abstract

A disposable screen-printed electrode based on a graphite and polyurethane resin composite (EIGPU) was developed and evaluated as a voltammetric detector in pharmaceutical analysis. Using cyclic voltammetry, an analytical curve was obtained with the linear dynamic range between 1.00100 mu mol L-1 and a detection limit of 8.18 x 10-7 mol L-1 for acetaminophen (paracetamol) as a probe. During the APAP determination in pharmaceutical formulations, recoveries between 97.2 and 102% were found. There were no interferences from ascorbic acid and other constituents of the pharmaceutical formulation at the 95% confidence level compared to HPLC analysis. (AU)

• FAPESP's process: 10/06485-8 - Development and application of screen printed and rod graphite and polyurethane based composite electrodes and molecularly imprinted polymers for analytical purposes
• Grantee: Priscila Cervini
• Support Opportunities: Regular Research Grants
• FAPESP's process: 10/11080-7 - Preparation and application of grafite-polimer based composite electrodes : modification with organofunctionalized silicas and molecurlay imprinted polymers
• Grantee: Éder Tadeu Gomes Cavalheiro
• Support Opportunities: Regular Research Grants
• FAPESP's process: 10/05913-6 - Development and application of screen printed electrodes based on graphite and polyurethane composites
• Grantee: Thalita Rocha Saciloto
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)