Studies toward the synthesis of Amaryllidaceae alkaloids from Morita-Baylis-Hillman adducts: a straightforward synthesis of functionalized dihydroisoquinolin-5(6H)-one core

Elizandra C.S. Lopes; Fernando Coelho

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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Studies toward the synthesis of Amaryllidaceae alkaloids from Morita-Baylis-Hillman adducts: a straightforward synthesis of functionalized dihydroisoquinolin-5(6H)-one core

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Author(s):	Elizandra C.S. Lopes ^[1] ; Fernando Coelho ^[2] Total Authors: 2
Affiliation:	^[1] Universidade Estadual de Campinas. Instituto de Química - Brasil ^[2] Universidade Estadual de Campinas. Instituto de Química - Brasil Total Affiliations: 2
Document type:	Journal article
Source:	Journal of the Brazilian Chemical Society; v. 18, n. 7, p. 1415-1438, 2007-00-00.
Abstract
We disclose herein our results concerning a study aiming at the synthesis of the highly substituted carbon skeleton of alkaloids isolated from plants of the Amaryllidaceae family. The total synthesis of the functionalized dihydroisoquinolin-5(6H)-one core, which is the bottom part of the structure of alkaloids isolated from this botanic family, is described, using Morita-Baylis-Hillman adducts as substrate. This compound should be a useful and valuable intermediate for the total synthesis of alkaloids isolated from Amaryllidaceae. (AU)

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